Polymers for pro- and anti-angiogenic therapy.

Polymers for pro- and anti-angiogenic therapy. Research Abstract Details 

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Polymers for pro- and anti-angiogenic therapy. Abstract Text:

Claudia Fischbach,David J Mooney,

Dysregulated growth factor signaling is traditionally targeted via bolus injections of therapeutic molecules, but this approach may not recreate necessary qualitative and quantitative aspects of biologic growth factor delivery systems. Polymeric delivery systems may, instead, mimic certain sequestration and binding characteristics of the extracellular matrix and lead to the provision of therapeutic molecules at therapeutically efficient local concentrations [V], in the form of spatial gradients (d[V]/dx) and temporal gradients (d[V]/dt), and in combination with other morphogenetic cues. Both physicochemical and biological attributes dictate their design, and they may be fabricated from synthetic and natural polymers. General concepts for manipulating growth factor signaling with these systems are discussed in the context of angiogenesis with vascular endothelial growth factor (VEGF), and these strategies may be broadly adapted to a multitude of other morphogens and growth factors.

Polymers for pro- and anti-angiogenic therapy. Publishing Authors By Initials

C Fischbach,DJ Mooney,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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Polymers for pro- and anti-angiogenic therapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Biomaterials

VOLUME: 28

Page Numbers: 2069-76

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 10

MONTH: 01

YEAR: 2007

Polymers for pro- and anti-angiogenic therapy. Information

Number of References: 71

LANGUAGE: eng

NlmUniqueID: 8100316

Polymers for pro- and anti-angiogenic therapy. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Polymers for pro- and anti-angiogenic therapy. Information

Substance Name: Polymers

Registry Number: 0

Grant and Affiliation Information for Polymers for pro- and anti-angiogenic therapy.

AFFILIATION: Division of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA.

Country: England

AGENCY: United States NIDCR

GRANT: R37 DE013033

ACRONYM: DE

MEDLINETA: Biomaterials

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