Polymeric micelles for drug delivery.

Polymeric micelles for drug delivery. Research Abstract Details 

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Polymeric micelles for drug delivery. Abstract Text:

S R Croy,G S Kwon,

Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes. An emphasis of this review has been placed on both the description and characterization techniques of the physical properties of polymeric micelles. Relevant properties discussed include micellar association, morphology, size and stability. These properties and characterization techniques are included to provide context for the known advantages and applications of polymeric micelles for drug delivery. The advantages and applications discussed include solubilization of poorly soluble molecules, sustained release and size advantages, and protection of encapsulated substances from degradation and metabolism. The three most widely studied block copolymer classes are characterized by their hydrophobic blocks, and are poly(propylene oxide), poly(L-amino acid)s and poly(ester)s. These three classes of block copolymers are reviewed with multiple examples of current research in which formulation techniques with polymeric micelles have been applied to some of the most challenging molecules in the pharmaceutical industry. The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.

Polymeric micelles for drug delivery. Publishing Authors By Initials

SR Croy,GS Kwon,

For similar natural sciences: chemistry: chemistry, physical: surface properties research abstracts see: natural sciences: chemistry: chemistry, physical: surface properties research

PUBMED ID PMID:

MEDLINE DATE:

Polymeric micelles for drug delivery. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical design

VOLUME: 12

Page Numbers: 4669-84

Journal Abbreviation: Curr. Pharm. Des.

ISSN: 1873-4286

DAY: 3

MONTH: 12

YEAR: 2006

Polymeric micelles for drug delivery. Information

Number of References: 157

LANGUAGE: eng

NlmUniqueID: 9602487

Polymeric micelles for drug delivery. Keywords Mesh Terms:

KEYWORDS: Surface Properties

MESH TERMS: chemistry

Chemical & Substance for Abstract: Polymeric micelles for drug delivery. Information

Substance Name: polypropylene glycol

Registry Number: 25322-69-4

Grant and Affiliation Information for Polymeric micelles for drug delivery.

AFFILIATION: School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: AI-43346-08

ACRONYM: AI

MEDLINETA: Curr Pharm Des

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