Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS.

Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS. Research Abstract Details 

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Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS. Abstract Text:

Simon ,Lars Wallman, Helldin,Johan Nilsson, Marko-Varga,Thomas Laurell,Simon ,Lars Wallman, Helldin,Johan Nilsson, Marko-Varga,Thomas Laurell,

A polymer microfabricated proteomic sample preparation and MALDI MS sample presentation device, the integrated selective enrichment target (ISET), comprising an array of perforated nanovials is reported. Each perforated nanovial can be filled with selective extraction media (microbeads) for purification and concentration of protein/peptides prior to matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). The main areas covered are the influence of the molding-process-induced surface roughness and how to address the lack of inherent conductivity in the polyetheretherketone (PEEK) material for optimal MALDI MS readout. Application of the disposable polymeric ISET devices for solid-phase extraction and phosphopeptide capture is also demonstrated.

Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS. Publishing Authors By Initials

S ,L Wallman,G Helldin,J Nilsson,G Marko-Varga,T Laurell,S ,L Wallman,G Helldin,J Nilsson,G Marko-Varga,T Laurell,

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Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of mass spectrometry : JMS

VOLUME: 42

Page Numbers: 1445-52

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ISSN: 1076-5174

DAY: 31

MONTH: Nov

YEAR: 2007

Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS. Information

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LANGUAGE: eng

NlmUniqueID: 9504818

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Grant and Affiliation Information for Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS.

AFFILIATION: Department of Electrical Measurements, Lund Institute of Technology, S-221 00, Sweden. simon.ekstrom@elmat.lth.se

Country: England

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MEDLINETA: J Mass Spectrom

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