Polymeric contrast agents for medical imaging.

Polymeric contrast agents for medical imaging. Research Abstract Details 

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Polymeric contrast agents for medical imaging. Abstract Text:

Synthetic polymers and co-polymers are described, to be used as carriers of reporter groups for gamma-, magnetic resonance (MR), and computed tomography (CT) imaging. Those compounds include polychelating and amphiphilic polymers and serve as key components of various contrast agents. Single terminus-activated polychelating polymers were synthesized using poly-L-lysine (PLL) as a main chain and chelating moieties (such as diethylene triamine pentaacetic acid or DTPA) as side groups. These polymers were used for the modification of diagnostic monoclonal antibodies to increase their load with reporter metal atoms. As a result, better images within shorter time intervals were obtained in animal experiments. The application of liposomes and micelles as carriers for diagnostic imaging agents in experimental and clinical medicine is considered. The load of liposomes and micelles with contrast agents for gamma- and MR imaging (MRI) was sharply increased by using polychelating polymers additionally modified on one end with a hydrophobic phospholipid residue to give amphiphilic polymers. Such polymers easily incorporate the liposome membrane or micelle core and provide better loading of liposomes and micelles with reporter metals and, consequently, better and faster imaging of various physiological compartments, such as lymphatic and vascular systems. A block-copolymer of methoxy-poly(ethylene glycol) (MPEG) and iodine-substituted PLL was synthesized to prepare long-circulating contrast agent for CT imaging of the blood pool. In the aqueous solution, this copolymer forms stable and heavily loaded with iodine (up to 30% of iodine by weight) micelles. These micelle were successfully used for CT visualization of the vascular network in experimental animals. General trends in developing contrast polymers are discussed.

Polymeric contrast agents for medical imaging. Publishing Authors By Initials

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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Polymeric contrast agents for medical imaging. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical biotechnology

VOLUME: 1

Page Numbers: 183-215

Journal Abbreviation: Curr Pharm Biotechnol

ISSN: 1389-2010

DAY: 12

MONTH: Sep

YEAR: 2000

Polymeric contrast agents for medical imaging. Information

Number of References: 97

LANGUAGE: eng

NlmUniqueID: 100960530

Polymeric contrast agents for medical imaging. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: chemistry

Chemical & Substance for Abstract: Polymeric contrast agents for medical imaging. Information

Substance Name: Polymers

Registry Number: 0

Grant and Affiliation Information for Polymeric contrast agents for medical imaging.

AFFILIATION: Department of Pharmaceutical Science, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA.

Country: Netherlands

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MEDLINETA: Curr Pharm Biotechnol

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