Polymer platforms for drug delivery and biomedical imaging.

Polymer platforms for drug delivery and biomedical imaging. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Polymer platforms for drug delivery and biomedical imaging. Abstract Text:

Zheng-Rong Lu,Furong Ye,Anagha Vaidya,

Biocompatible synthetic polymers have demonstrated advantageous pharmacokinetic properties as compared to small molecular agents. Incorporation of low molecular weight therapeutics and imaging agents into biocompatible polymers can optimize their pharmacokinetic properties with improved efficacy of therapy and diagnostic imaging, respectively. We have applied the concept of drug delivery to design safe and effective contrast agents for magnetic resonance imaging (MRI) and used biomedical imaging in non-invasive evaluation of drug delivery and image-guided therapy. We summarize here the recent progress in our research on biodegradable macromolecular MRI contrast agents, non-invasive visualization of in vivo drug delivery of polymeric conjugates with contrast enhanced MRI, and contrast enhanced MRI guided photodynamic therapy. The preliminary results have shown that biocompatible polymers can be used as an effective platform for drug delivery and biomedical imaging. Safe and effective imaging agents can be designed by using the concept of polymeric drug delivery. Biomedical imaging can be used as a non-invasive method for the evaluation of in vivo drug delivery of polymeric drug delivery systems. The combination of drug delivery and biomedical imaging can result in image-guided therapies, which include tumor detection, therapy and non-invasive evaluation of therapeutic responses.

Polymer platforms for drug delivery and biomedical imaging. Publishing Authors By Initials

ZR Lu,F Ye,A Vaidya,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

PUBMED ID PMID:

MEDLINE DATE:

Polymer platforms for drug delivery and biomedical imaging. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of controlled release : official journal o

VOLUME: 122

Page Numbers: 269-77

Journal Abbreviation:

ISSN: 1873-4995

DAY: 27

MONTH: 06

YEAR: 2007

Polymer platforms for drug delivery and biomedical imaging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8607908

Polymer platforms for drug delivery and biomedical imaging. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Polymer platforms for drug delivery and biomedical imaging. Information

Substance Name: Gadolinium

Registry Number: 7440-54-2

Grant and Affiliation Information for Polymer platforms for drug delivery and biomedical imaging.

AFFILIATION: Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84108, United States. zhengrong.lu@utah.edu

Country: Netherlands

AGENCY: United States NCI

GRANT: R21/R33 CA095873

ACRONYM: CA

MEDLINETA: J Control Release

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Polymer platforms for drug delivery and biomedical imaging Related Publications

• A POINT IN FAVOUR OF PROFESSOR ARTHUR THOMSON'S THEORY OF THE PRODUCTION OF GLAUCOMA.
• Acute renal failure secondary to oxalosis in a recipient of a simultaneous kidney-pancreas transplant: was mycophenolate the cause?
• Analysis of gross deletions in the MEN1 gene in patients with multiple endocrine neoplasia type 1.
• Anti-phospholipid antibody-mediated rejection.
• Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus.
• Atypical neural substrates of Embedded Figures Task performance in children with Autism Spectrum Disorder.
• Biomechanical analysis of differing pedicle screw insertion angles.
• Carpopedal spasm in an elderly man: an unusual presentation of coeliac disease.
• Clinical importance of anti-human leukocyte antigen-specific antibody concentration in performing calculated panel reactive antibody and virtual crossmatches.
• Cocirculation of and coinfections with hepatitis A virus subgenotypes IIIA and IB in patients from Pune, western India.
• Development of a real-time polymerase chain reaction assay for the quantification of Leishmania species and the monitoring of systemic distribution of the pathogen.
• Developmental differences in cognitive control of socio-affective processing.
• Early antiretroviral therapy: The pendulum shifts again.
• Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats.
• Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides.
• Influence of fluoride containing toothpaste on serum and urine fluoride levels in children.
• Mathematical modelling of radiotherapy strategies for early breast cancer.
• Method to test whether late extended letrozole, rather than self- selection, improves the outcome in patients with breast cancer who have completed 5 years of tamoxifen.
• Mitochondrial drug targets in apicomplexan parasites.
• Novel technologies for the discovery and quantitation of biomarkers of toxicity.
• Plasmodium vivax malaria in spite of atovaquone/proguanil (malarone) prophylaxis.
• Platelet Inhibition by Aspirin 81 and 325 mg/day in Men Versus Women Without Clinically Apparent Cardiovascular Disease.
• Platelet functional implications of glycoprotein Ibalpha polymorphisms in African Americans.
• Polymer platforms for drug delivery and biomedical imaging.
• Psychiatry Clerkship Objective Structured Clinical Examination is Here to Stay.
• Pyridine biodegradation in a novel rotating rope bioreactor.
• Racial differences of lipoprotein subclass distributions in postmenopausal women.
• Re: Declines in invasive breast cancer and use of postmenopausal hormone therapy in a screening mammography population.
• Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus.
• Vitamin D and cancer.