Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans.

Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans. Research Abstract Details 

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Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans. Abstract Text:

R Narayani,K P Rao,

In oral delivery of protein and peptide drugs there is a great need for suitable devices for delivering the therapeutic agent-incorporated microspheres selectively in the intestine. It is essential that the drug-loaded multiple unit carrier system should be protected from the harsh environment of the stomach and deliver the carrier system in the large intestine where drug action or absorption is desired. Gelatin capsules were coated with various concentrations of sodium alginate and cross-linked with appropriate concentrations of calcium chloride and tested in vitro for resistance to gastric and intestinal medium. Gelatin capsules coated with 20% w/v of the polymer which gave the most promising result in vitro were evaluated in human volunteers for their in vivo gastro intestinal tract behaviour. The radiographical studies show that while the uncoated gelatin capsules disintegrated in the stomach within 15 min of ingestion, the alginate coated gelatin capsules remained intact as long as they were retained in the stomach (up to 3 h) and then migrated to the ileocecal region of the intestine and disintegrated.

Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans. Publishing Authors By Initials

R Narayani,KP Rao,

For similar proteins research abstracts see: proteins research

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Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 7

Page Numbers: 39-48

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1995

Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans. Information

Substance Name: alginic acid

Registry Number: 9005-32-7

Grant and Affiliation Information for Polymer-coated gelatin capsules as oral delivery devices and their gastrointestinal tract behaviour in humans.

AFFILIATION: Biomaterials Department, Central Leather Research Institute, Adyar, Madras, India.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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