Peptides, Cyclic

- A deacylation enzyme for aculeacin A, a neutral lipopeptide antibiotic, from Actinoplanes utahensis: purification and characterization. An enzyme, tentatively termed aculeacin A acylase, useful in preparing deacylated peptides which are used as starting material for semisynthetic antifungal...

- Antifungal cyclopeptolide from fungal saprophytic antagonist Ulocladium atrum. The saprophytic fungus Ulocladium atrum Preuss is a promising biological control agent for Botrytis cinerea in greenhouse- and field-grown crops. However,...

- Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity. Tachyplesin is an antimicrobial peptide recently found in the acid extract of hemocytes from the Japanese horseshoe crab (Tachypleus tridentatus) [Nakamura,...

- Cryptococcal fungemia in a neutropenic patient with AIDS while receiving caspofungin. Empiric choice of anti-fungal therapy in febrile neutropenia should be based upon a host's susceptibility to specific fungal pathogens. We present a case of...

- Cytotoxicity of cyanobacterium Microcystis aeruginosa. Cytotoxic effects of crude extracts and fractions of the purification steps towards Microcystin-LR (MCYST-LR) were investigated in vitro. Cytotoxicity was...

- Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. Ramoplanin is a potent cyclic lipoglycodepsipeptide antibiotic that disrupts bacterial cell wall synthesis by binding to the peptidoglycan intermediate Lipid...

- Effects of MIF-1 and its cyclic derivative alaptide on agonistic behaviour in mice.

- Efficacy of amphotericin B or amphotericin B-intralipid in combination with caspofungin against experimental aspergillosis. OBJECTIVE: Infections caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. The objective of this study was...

- Engineering metal complexes of chiral pentaazacrowns as privileged reverse-turn scaffolds. Reverse turns are common structural motifs and recognition sites in protein/protein interactions. The design of peptidomimetics is often based on replacing...

- Indirect covariance NMR spectroscopy. A novel NMR scheme is presented that establishes homonuclear spin correlations without requiring direct detection of the spin species. This covariance NMR...

- Metal analogues of mycobactin and exochelin fail to act as effective antimycobacterial agents. Mycobactins and exochelins from mycobacteria formed complexes with many heavy metals in the absence of iron. Although many of these complexes affected the...

- Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis. BACKGROUND: Micafungin (FK463) is a new lipopeptide compound (echinocandin) with activity against Aspergillus and Candida species. This study evaluated the...

- Participation of iron on the growth inhibition of pathogenic strains of mycobacterium avium and M. paratuberculosis in serum. Serum, which is low in freely-available iron, was bacteriostatic for M. avium and M. paratuberculosis irrespective of the ability of these organisms to...

- Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp. The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these...

- Synthesis of amino acid-derived cyclic acyl amidines for use in beta-strand peptidomimetics. The acyl amidine represented by the 4,5-dihydro-2(3H)-pyrazinone ring system 2 is isosteric to the vinylogous amide of the 1,2-dihydro-3(6H)-pyridinone 1,...

- The spectrum of antimicrobial activity of the bacteriocin subtilosin A. BACKGROUND: Bacterocins are antimicrobial peptides produced by bacteria with a relatively narrow range of activity against closely related organisms....