Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort.

Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Research Abstract Details 

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Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Abstract Text:

Rachel L Miller,Robin Garfinkel,Megan Horton,David Camann,Frederica P Perera,Robin M Whyatt,Patrick L Kinney,

STUDY OBJECTIVES: Several studies have found associations between diesel exposure, respiratory symptoms, and/or impaired pulmonary function. We hypothesized that prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAH), important components of diesel exhaust and other combustion sources, may be associated with respiratory symptoms in young children. We also hypothesized that exposure to environmental tobacco smoke (ETS) may worsen symptoms beyond that observed to be associated with PAH alone.Design/participants: To test our hypotheses, we recruited 303 pregnant women from northern Manhattan believed to be at high risk for exposure to both PAH and ETS, collected 48-h personal PAH exposure measurements, and monitored their children prospectively. RESULTS: By 12 months of age, more cough and wheeze were reported in children exposed to prenatal PAH in concert with ETS postnatally (PAH x ETS interaction odds ratios [ORs], 1.41 [p < 0.01] and 1.29 [p < 0.05], respectively). By 24 months, difficulty breathing and probable asthma were reported more frequently among children exposed to prenatal PAH and ETS postnatally (PAH x ETS ORs, 1.54 and 1.64, respectively [p < 0.05]). CONCLUSIONS: Our results suggest that early exposure to airborne PAH and ETS can lead to increased respiratory symptoms and probable asthma by age 12 to 24 months. Interventions to lower the risk of respiratory disease in young children living in the inner city may need to address the importance of multiple environmental exposures.

Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Publishing Authors By Initials

RL Miller,R Garfinkel,M Horton,D Camann,FP Perera,RM Whyatt,PL Kinney,

For similar population characteristics: population: urban population research abstracts see: population characteristics: population: urban population research

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Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Chest

VOLUME: 126

Page Numbers: 1071-8

Journal Abbreviation: Chest

ISSN: 0012-3692

DAY: 5

MONTH: Oct

YEAR: 2004

Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Information

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LANGUAGE: eng

NlmUniqueID: 231335

Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Keywords Mesh Terms:

KEYWORDS: Urban Population

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Information

Substance Name: Tobacco Smoke Pollution

Registry Number: 0

Grant and Affiliation Information for Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort.

AFFILIATION: Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, PH8C, 630 168th Street, New York, NY 10032, USA. rlm14@columbia.edu

Country: United States

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MEDLINETA: Chest

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