Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique.

Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique. Research Abstract Details 

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Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique. Abstract Text:

A Sinaga,T A Hatton,K C Tam,

Secondary structure formation in four novel hybrid poly(acrylic acid)-b-poly(L-valine) (PAA-b-PLVAL) block copolymers, that is, PAA(40)-PLVAL(100), PAA(80)-PLVAL(100), PAA(80)-PLVAL(80), and PAA(80)-PLVAL(60), was investigated by circular dichroism. The formation of stable and well-defined beta-sheet structure in the PLVAL hydrophobic domains was observed for all the copolymers. At pH 5, PAA(80)-PLVAL(60) with the lowest PLVAL/PAA molar ratio possessed the lowest beta-sheet content of 12%, and it increased to 62% for PAA(40)-PLVAL(100) system. The beta-sheet formation in the block copolymers was controlled by both random PAA-PLVAL hydrogen bonds at low pH and electrostatic repulsive forces on the PAA segment at high pH; hence, the beta-sheet structure was most stable at intermediate pH. The length of PAA segments was critical in the beta-sheet solubilization and in providing sufficient shielding of the hydrophobic core from denaturing agents such as urea.

Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique. Publishing Authors By Initials

A Sinaga,TA Hatton,KC Tam,

For similar organic chemicals: urea research abstracts see: organic chemicals: urea research

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Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomacromolecules

VOLUME: 8

Page Numbers: 2801-8

Journal Abbreviation: Biomacromolecules

ISSN: 1525-7797

DAY: 21

MONTH: 08

YEAR: 2007

Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892849

Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique. Keywords Mesh Terms:

KEYWORDS: Urea

MESH TERMS: chemistry

Chemical & Substance for Abstract: Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique. Information

Substance Name: carbopol 940

Registry Number: 9003-01-4

Grant and Affiliation Information for Poly(acrylic acid)-block-poly(L-valine): evaluation of beta-sheet formation and its stability using circular dichroism technique.

AFFILIATION: Singapore--MIT Alliance, National University of Singapore E4-B-07/8, 4 Engineering Drive 3, Singapore 117576.

Country: United States

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MEDLINETA: Biomacromolecules

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