Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection.

Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. Abstract Text:

In contrast to the detrimental outcomes most often associated with the resolution of coinfections, the model presented here involving a localized Pneumocystis infection of the lung, followed 2 wk later by an influenza virus infection, results in a significant beneficial outcome for the host. In the week following the influenza infection, immunocompetent coinfected animals exhibited an accelerated rate of virus clearance, an accelerated appearance of higher influenza-specific neutralizing Ab titers in their serum and bronchoalveolar lavage fluid (BALF), significantly reduced inflammatory cytokine levels in their BALF, and reduced levels of morbidity relative to animals infected only with influenza virus. The beneficial outcome observed in coinfected immunocompetent animals was dependent on the ongoing resolution of a viable Pneumocystis infection. No differences in viral clearance were detected between coinfected and influenza-only-infected muMT mice or likewise for SCID mice. The accelerated anti-influenza response did not appear to be associated with influenza-specific CD8 T cell-mediated responses or NK cell responses in the lung. Rather, the increased rate of viral clearance was due to the enhancement of the influenza-specific Ab response, which in turn was transiently dependent upon the resolution of the ongoing Pneumocystis infection.

Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 180

Page Numbers: 5613-24

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Apr

YEAR: 2008

Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection.

AFFILIATION: Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59715.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection Related Publications

• Automated polyp measurement with CT colonography: preliminary observations in a phantom colon model.
• Based Upon Repeat Pattern (BURP): an algorithm to characterize the long-term evolution of Staphylococcus aureus populations based on spa polymorphisms.
• Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction.
• Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection.
• Dependence of neovascularization mechanisms on the molecular microenvironment.
• Electron microscopical study of muscle biopsies from healthy young people. Methodology and results.
• EpCAM homologues exhibit epithelial-specific but different expression patterns in the kidney.
• EpCAM in morphogenesis.
• Evaluation of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry in comparison to 16S rRNA gene sequencing for species identification of nonfermenting bacteria.
• Is preservation of hearing in acoustic neuroma worthwhile?
• Measuring bioavailability: from a scientific approach to standard methods.
• Neutrophils and inducible nitric-oxide synthase are critical for early resistance to the establishment of Tritrichomonas foetus infection.
• Oral health & the senior patient.
• Physical symptoms that predict psychiatric disorders in rural primary care adults.
• Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection.
• Pulmonary hypertension can be a sequela of prior Pneumocystis pneumonia.
• Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus.
• Reducing data size and radiation dose for CT colonography.
• Results of translabyrinthine removal of 300 acoustic neuromas related to tumour size.
• Single-pass CT of hepatic tumors: value of globular enhancement in distinguishing hemangiomas from hypervascular metastases.
• Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys.
• Total shoulder arthroplasty versus hemiarthroplasty for rheumatoid arthritis of the shoulder: results of 303 consecutive cases.
• Tritrichomonas foetus: pathogenesis of acute infection in normal, estradiol-treated, and stressed mice.
• Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung.
• Vascular smooth muscle cells for use in vascular tissue engineering obtained by endothelial-to-mesenchymal transdifferentiation (EnMT) on collagen matrices.
• [Death from malignant hyperthermia during anaesthesia (author's transl)]
• [Demographic, economic, and social consequences of a stationary or declining population development in Europe]
• [Epidemics and their change from a social hygienic viewpoint.]
• [Not Available.]
• [Social hygiene studies on the problem of retirement.]