Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience.

Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience. Abstract Text:

S Chris Malaisrie,Marc P Pelletier,James J Yun,Kapil Sharma,Tomasz A Timek,David N Rosenthal,Gail E Wright,Robert C Robbins,Bruce A Reitz,S Chris Malaisrie,Marc P Pelletier,James J Yun,Kapil Sharma,Tomasz A Timek,David N Rosenthal,Gail E Wright,Robert C Robbins,Bruce A Reitz,

BACKGROUND: Mechanical circulatory support with the Berlin Heart EXCOR pediatric ventricular assist device (VAD) has been used successfully in Europe for children with cardiac failure. Eighty-seven devices have been placed in North America through February 2007. We describe our single-center experience in 8 children. METHODS: Eight children (ages 4 to 55 months), with median weight of 9.6 kg and body surface area of 0.48 m(2), received the Berlin Heart VAD as a bridge to transplantation. All patients were in cardiogenic shock requiring multiple inotropes. Primary diagnoses were idiopathic dilated cardiomyopathy (n = 4), congenital heart disease (n = 3) and restrictive cardiomyopathy (n = 1). After device insertion, all patients were treated with an anti-coagulant (heparin or coumadin) and one or more platelet inhibitors (aspirin with clopidogrel or dipyridamole). RESULTS: Five patients received support with a left ventricular assist device (LVAD) and 3 with a biventricular device (BiVAD). Duration of support ranged from 2 to 234 days (median 57 days). Five patients (63%) were successfully bridged to transplantation; of these, 4 were discharged home and 1 died from early graft failure. Five patients developed post-operative neurologic events. Of these 5 events, 4 could be explained by embolism or hemorrhage. Device exchange was performed in 4 patients in the intensive care unit. CONCLUSIONS: In selected children, the Berlin Heart VAD can be used as a bridge to transplantation. In contrast to the published European experience, neurologic events occur frequently. Anti-coagulation and platelet inhibition strategies continue to evolve. Device exchange is technically feasible at the bedside and should be considered at the earliest visualization of thrombus formation.

Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience. Publishing Authors By Initials

SC Malaisrie,MP Pelletier,JJ Yun,K Sharma,TA Timek,DN Rosenthal,GE Wright,RC Robbins,BA Reitz,SC Malaisrie,MP Pelletier,JJ Yun,K Sharma,TA Timek,DN Rosenthal,GE Wright,RC Robbins,BA Reitz,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of heart and lung transplantation : th

VOLUME: 27

Page Numbers: 173-7

Journal Abbreviation: J. Heart Lung Transplant.

ISSN: 1557-3117

DAY: 12

MONTH: Feb

YEAR: 2008

Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9102703

Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience.

AFFILIATION: Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305-5407, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Heart Lung Transplant

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience Related Publications

• "One-and-half ventricle" cardiac transplantation for complex congenital heart disease.
• 8-(Heteroaryl)phenalkyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-ones as opioid receptor modulators.
• A cross-sectional study of bone turnover markers in healthy premenopausal women.
• A review of present methods in the early diagnosis of bronchogenic carcinoma.
• An alteration of human immunodeficiency virus gp41 leads to reduced CCR5 dependence and CD4 independence.
• Antibiotic effects of circulin against certain gram-negative plant pathogens.
• Basic principles governing animals and their treatment.
• Can the ice-water test predict the outcome of intradetrusor injections of botulinum toxin in patients with neurogenic bladder dysfunction?
• Cisplatin, gemcitabine and treosulfan is effective in chemotherapy-pretreated relapsed stage IV uveal melanoma patients.
• Cisplatin, gemcitabine, and treosulfan in relapsed stage IV cutaneous malignant melanoma patients.
• Competitive exclusion of a worldwide invasive pest by a native. Quantifying competition between two phytophagous insects on two host plant species.
• Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa.
• Ecology. Invasion of the whiteflies.
• Editorial comment on: effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve.
• Filling the pipeline for neglected diseases: creation of a medicinal chemistry-centric international drug discovery institute [iDDi].
• Fractional polynomials in a new metastatic renal carcinoma continuous prognostic index involving histology, laboratory, and clinical predictors.
• Heart lung transplantation.
• Metabolic fate of the antipsychotic agent, mazapertine, in man--API-MS and MS/MS identification of urinary metabolites.
• Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).
• Peripheral Blood Neutrophils as Independent Immunologic Predictor of Response and Long-Term Survival upon Immunotherapy in Metastatic Renal-Cell Carcinoma.
• Pneumatic paracorporeal ventricular assist device in infants and children: initial Stanford experience.
• Safety assessment of dairy microorganisms: Bacterial taxonomy.
• The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.
• Twenty-year survivors of heart transplantation at stanford university.