Pleural fluid exchange in rabbits.

Pleural fluid exchange in rabbits. Research Abstract Details 

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Pleural fluid exchange in rabbits. Abstract Text:

Gregg J Stashenko,Amy Robichaux,Y C Gary Lee,Jonathan R Sanders,Robert J Roselli,Richard W Light,

BACKGROUND AND OBJECTIVES: The study was designed to better characterize pleural fluid absorption in rabbits with the following two objectives: to determine the relative absorption of saline versus high-protein solutions, and to identify the relative rates of absorption of dextran molecules of varying sizes. METHODS: Twenty New Zealand white rabbits received a 12-mL intrapleural injection of saline solution and a 10% protein solution on opposite sides, each solution containing dextran molecules with varying MWs. At sacrifice at 1, 4, 8, 18 and 24 h, the volume of pleural fluid and the concentrations of the dextran molecules were determined. RESULTS: Saline was absorbed faster than the high-protein fluid (P < 0.001). Dextran concentrations in the saline were significantly higher than those in the protein solution at all times after injection (P = 0.005; P < 0.001, respectively). The higher-MW dextrans were cleared more slowly than the lower-MW dextrans in a continuously graded manner. CONCLUSIONS: Saline was absorbed faster than a solution with a high protein content. There was a continuous spectrum in the rate of absorption of the dextran molecules, with the larger molecules being absorbed more slowly.

Pleural fluid exchange in rabbits. Publishing Authors By Initials

GJ Stashenko,A Robichaux,YC Lee,JR Sanders,RJ Roselli,RW Light,

For similar pharmaceutical preparations: solutions: hypertonic solutions: saline solution, hypertonic research abstracts see: pharmaceutical preparations: solutions: hypertonic solutions: saline solution, hypertonic research

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Pleural fluid exchange in rabbits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Respirology (Carlton, Vic.)

VOLUME: 12

Page Numbers: 495-9

Journal Abbreviation: Respirology

ISSN: 1323-7799

DAY: 3

MONTH: Jul

YEAR: 2007

Pleural fluid exchange in rabbits. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9616368

Pleural fluid exchange in rabbits. Keywords Mesh Terms:

KEYWORDS: Saline Solution, Hypertonic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pleural fluid exchange in rabbits. Information

Substance Name: Dextrans

Registry Number: 9004-54-0

Grant and Affiliation Information for Pleural fluid exchange in rabbits.

AFFILIATION: Department of Medicine, Saint Thomas Hospital, Division of Allergy, Critical Care and Pulmonary Diseases, Vanderbilt University, Nashville, Tennessee, USA.

Country: Australia

AGENCY: United States NHLBI

GRANT: R01 HL51234

ACRONYM: HL

MEDLINETA: Respirology

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