Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter.

Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter. Research Abstract Details 

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Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter. Abstract Text:

Willibald Hochholzer,Daniel Schlittenhardt,Thomas Arentz,Jochem Stockinger,Reinhold Weber,Gerd ,Dietrich Kalusche,Dietmar Trenk,Franz-Josef Neumann,

AIMS: Lower platelet activation by cryoenergy compared with radiofrequency (RF) energy was recently demonstrated immediately following ablation procedures of cardiac arrhythmias. Due to the delayed occurrence of cryolesions it is currently unknown, if cryoenergy and RF energy are associated with similar platelet activation and myocardial necrosis in the days after the procedure. METHODS AND RESULTS: We enrolled 38 patients with common atrial flutter undergoing cavotricuspid isthmus ablation with either RF energy (n = 23) or cryoenergy (n = 13). Ten patients undergoing RF ablation and receiving aspirin served as antiplatelet control group. Troponin T and platelet surface protein expression of P-selectin were determined before and immediately after ablation as well as on day 1 and 2 thereafter. Rise in troponin T was amplified after RF ablation (0.50 +/- 0.37 microg/L) when compared with cryoablation (0.24 +/- 0.20 microg/L; P = 0.024). In patients without aspirin, a significant increase in P-selectin expression was observed on day 1 after intervention in RF ablation compared with cryoablation (80 +/- 26 vs. 63 +/- 16 arbitrary units; P = 0.048). Platelet activation was attenuated in patients receiving aspirin. CONCLUSION: Successful ablation of atrial flutter with cryoenergy is associated with less myocardial necrosis and platelet activation compared with ablation with RF energy. Increased platelet activation following RF ablation can be attenuated by concomitant treatment with aspirin.

Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter. Publishing Authors By Initials

W Hochholzer,D Schlittenhardt,T Arentz,J Stockinger,R Weber,G ,D Kalusche,D Trenk,FJ Neumann,

For similar macromolecular substances: polymers: biopolymers: microfilament proteins: troponin: troponin t research abstracts see: macromolecular substances: polymers: biopolymers: microfilament proteins: troponin: troponin t research

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Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Europace : European pacing, arrhythmias, and cardi

VOLUME: 9

Page Numbers: 490-5

Journal Abbreviation:

ISSN: 1099-5129

DAY: 9

MONTH: 05

YEAR: 2007

Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter. Information

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LANGUAGE: eng

NlmUniqueID: 100883649

Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter. Keywords Mesh Terms:

KEYWORDS: Troponin T

MESH TERMS: blood

Chemical & Substance for Abstract: Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter. Information

Substance Name: Aspirin

Registry Number: 50-78-2

Grant and Affiliation Information for Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter.

AFFILIATION: Herz-Zentrum Bad Krozingen, Suedring 15, 79189, Bad Krozingen, Germany. willibald.hochholzer@herzzentrum.de

Country: England

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MEDLINETA: Europace

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