Plasticity of recurring spatiotemporal activity patterns in cortical networks.

Plasticity of recurring spatiotemporal activity patterns in cortical networks. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Plasticity of recurring spatiotemporal activity patterns in cortical networks. Abstract Text:

Radhika Madhavan,Zenas C Chao,Steve M Potter,Radhika Madhavan,Zenas C Chao,Steve M Potter,

How do neurons encode and store information for long periods of time? Recurring patterns of activity have been reported in various cortical structures and were suggested to play a role in information processing and memory. To study the potential role of bursts of action potentials in memory mechanisms, we investigated patterns of spontaneous multi-single-unit activity in dissociated rat cortical cultures in vitro. Spontaneous spikes were recorded from networks of approximately 50 000 neurons and glia cultured on a grid of 60 extracellular substrate- embedded electrodes (multi-electrode arrays). These networks expressed spontaneous culture- wide bursting from approximately one week in vitro. During bursts, a large portion of the active electrodes showed elevated levels of firing. Spatiotemporal activity patterns within spontaneous bursts were clustered using a correlation-based clustering algorithm, and the occurrences of these burst clusters were tracked over several hours. This analysis revealed spatiotemporally diverse bursts occurring in well-defined patterns, which remained stable for several hours. Activity evoked by strong local tetanic stimulation resulted in significant changes in the occurrences of spontaneous bursts belonging to different clusters, indicating that the dynamical flow of information in the neuronal network had been altered. The diversity of spatiotemporal structure and long-term stability of spontaneous bursts together with their plastic nature strongly suggests that such network patterns could be used as codes for information transfer and the expression of memories stored in cortical networks.

Plasticity of recurring spatiotemporal activity patterns in cortical networks. Publishing Authors By Initials

R Madhavan,ZC Chao,SM Potter,R Madhavan,ZC Chao,SM Potter,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

PUBMED ID PMID:

MEDLINE DATE:

Plasticity of recurring spatiotemporal activity patterns in cortical networks. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physical biology

VOLUME: 4

Page Numbers: 181-93

Journal Abbreviation:

ISSN: 1478-3975

DAY: 9

MONTH: 10

YEAR: 2007

Plasticity of recurring spatiotemporal activity patterns in cortical networks. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101197454

Plasticity of recurring spatiotemporal activity patterns in cortical networks. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: physiology

Chemical & Substance for Abstract: Plasticity of recurring spatiotemporal activity patterns in cortical networks. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Plasticity of recurring spatiotemporal activity patterns in cortical networks.

AFFILIATION: Laboratory for Neuroengineering, Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS38628

ACRONYM: NS

MEDLINETA: Phys Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Plasticity of recurring spatiotemporal activity patterns in cortical networks Related Publications

• ASCCP Comprehensive Colposcopy Curriculum.
• Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons.
• Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
• Automated cryoEM data acquisition and analysis of 284742 particles of GroEL.
• Cataract surgery.
• Commentary: Orthopaedics and chiropractic, a close relationship.
• Does vitamin D stop inpatients falling? A randomised controlled trial.
• Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity.
• Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.
• Essentials of colposcopy education: the curriculum revised.
• Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women.
• Evaluation of bioreactor-cultivated bone by magnetic resonance microscopy and FTIR microspectroscopy.
• Exercise effect on weight and body fat in men and women.
• Folate and cancer--timing is everything.
• Genetic association studies of cancer: where do we go from here?
• Genetic tools to tailor cancer prevention by NSAIDs.
• IL6 genotypes and colon and rectal cancer.
• Inclusion of bovine serum albumin in semen extenders to enhance maintenance of stallion sperm viability.
• Influence of Campylobacter jejuni fliA, rpoN and flgK genes on colonization of the chicken gut.
• Manganese-enhanced magnetic resonance microscopy of mineralization.
• Maternal factors in prematurity.
• Monitoring cataract surgical outcomes moses C chirambo.
• Motility and fertility of equine spermatozoa extended in bovine serum albumin and sucrose.
• Plasticity of recurring spatiotemporal activity patterns in cortical networks.
• Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures.
• Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
• Region-specific network plasticity in simulated and living cortical networks: comparison of the center of activity trajectory (CAT) with other statistics.
• Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
• Setting up an Eye Service in the Republic of Benin.
• The predictive value of creatine kinase, EMG and MRI in diagnosing muscle disease.