Plasticity of functional connectivity in the adult spinal cord.

Plasticity of functional connectivity in the adult spinal cord. Research Abstract Details 

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Plasticity of functional connectivity in the adult spinal cord. Abstract Text:

L L Cai,G Courtine,A J Fong,J W Burdick,R R Roy,V R Edgerton,

This paper emphasizes several characteristics of the neural control of locomotion that provide opportunities for developing strategies to maximize the recovery of postural and locomotor functions after a spinal cord injury (SCI). The major points of this paper are: (i) the circuitry that controls standing and stepping is extremely malleable and reflects a continuously varying combination of neurons that are activated when executing stereotypical movements; (ii) the connectivity between neurons is more accurately perceived as a functional rather than as an anatomical phenomenon; (iii) the functional connectivity that controls standing and stepping reflects the physiological state of a given assembly of synapses, where the probability of these synaptic events is not deterministic; (iv) rather, this probability can be modulated by other factors such as pharmacological agents, epidural stimulation and/or motor training; (v) the variability observed in the kinematics of consecutive steps reflects a fundamental feature of the neural control system and (vi) machine-learning theories elucidate the need to accommodate variability in developing strategies designed to enhance motor performance by motor training using robotic devices after an SCI.

Plasticity of functional connectivity in the adult spinal cord. Publishing Authors By Initials

LL Cai,G Courtine,AJ Fong,JW Burdick,RR Roy,VR Edgerton,

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Plasticity of functional connectivity in the adult spinal cord. Journal Published:

PUBLICATION TYPE: Review

Journal: Philosophical transactions of the Royal Society of

VOLUME: 361

Page Numbers: 1635-46

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ISSN: 0962-8436

DAY: 29

MONTH: Sep

YEAR: 2006

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LANGUAGE: eng

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AFFILIATION: Bioengineering Option, California Institute of Technology, Pasadena, CA 91125-4100, USA.

Country: England

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MEDLINETA: Philos Trans R Soc Lond B Biol

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