Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes.

Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes. Research Abstract Details 

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Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes. Abstract Text:

Innate immune-related gene expression in the major disease vector mosquito Anopheles gambiae has been analyzed following infection by the malaria parasite, Plasmodium berghei. Substantially increased levels of mRNAs encoding the antibacterial peptide defensin and a putative Gram-negative bacteria-binding protein (GNBP) are observed 20-30 h after ingestion of an infected blood-meal, at a time which indicates that this induction is a response to parasite invasion of the midgut epithelium. The induction is dependent upon the ingestion of infective, sexual-stage parasites, and is not due to opportunistic co-penetration of resident gut micro-organisms into the hemocoel. The response is activated following infection both locally (in the midgut) and systemically (in remaining tissues, presumably fat body and/or hemocytes). The observation that Plasmodium can trigger a molecularly defined immune response in the vector constitutes an important advance in our understanding of parasite-vector interactions that are potentially involved in malaria transmission, and extends knowledge of the innate immune system of insects to encompass responses to protozoan parasites.

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Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 16

Page Numbers: 6114-9

Journal Abbreviation: EMBO J.

ISSN: 0261-4189

DAY: 15

MONTH: Oct

YEAR: 1997

Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes. Information

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LANGUAGE: eng

NlmUniqueID: 8208664

Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes. Keywords Mesh Terms:

KEYWORDS: Plasmodium berghei

MESH TERMS: immunology

Chemical & Substance for Abstract: Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes. Information

Substance Name: Insect Proteins

Registry Number: 0

Grant and Affiliation Information for Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes.

AFFILIATION: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. richman@embl-heidelberg.de

Country: ENGLAND

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MEDLINETA: EMBO J

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