Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions.

Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Research Abstract Details 

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Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Abstract Text:

Pedro Cabrales,Amy G Tsai,

The hamster window chamber model was used to study systemic and microvascular hemodynamic responses to extreme hemodilution with low- and high-viscosity plasma expanders (LVPE and HVPE, respectively) to determine whether plasma viscosity is a factor in homeostasis during extreme anemic conditions. Moderated hemodilution was induced by two isovolemic steps performed with 6% 70-kDa dextran until systemic hematocrit (Hct) was reduced to 18% (level 2). In a third isovolemic step, hemodilution with LVPE (6% 70-kDa dextran, 2.8 cP) or HVPE (6% 500-kDa dextran, 5.9 cP) reduced Hct to 11%. Systemic parameters, cardiac output (CO), organ flow distribution, microhemodynamics, and functional capillary density, were measured after each exchange dilution. Fluorescent-labeled microspheres were used to measure organ (brain, heart, kidney, liver, lung, and spleen) and window chamber blood flow. Final blood and plasma viscosities after the entire protocol were 2.1 and 1.4 cP, respectively, for LVPE and 2.8 and 2.2 cP, respectively, for HVPE (baseline = 4.2 and 1.2 cP, respectively). HVPE significantly elevated mean arterial pressure and CO compared with LVPE but did not increase vascular resistance. Functional capillary density was significantly higher for HVPE [87% (SD 7) of baseline] than for LVPE [42% (SD 11) of baseline]. Increases in mean arterial blood pressure, CO, and shear stress-mediated factors could be responsible for maintaining organ and microvascular perfusion after exchange with HVPE compared with LVPE. Microhemodynamic data corresponded to microsphere-measured perfusion data in vital organs.

Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Publishing Authors By Initials

P Cabrales,AG Tsai,

For similar biomechanics: stress, mechanical research abstracts see: biomechanics: stress, mechanical research

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Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Heart and circulat

VOLUME: 291

Page Numbers: H2445-52

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 26

MONTH: 05

YEAR: 2006

Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901228

Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Keywords Mesh Terms:

KEYWORDS: Stress, Mechanical

MESH TERMS: blood

Chemical & Substance for Abstract: Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Information

Substance Name: Dextrans

Registry Number: 9004-54-0

Grant and Affiliation Information for Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions.

AFFILIATION: La Jolla Bioengineering Institute, 505 Coast Blvd. South, La Jolla, CA 92037, USA. pcabrales@ucsd.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R24-HL-64395

ACRONYM: HL

MEDLINETA: Am J Physiol Heart Circ Physio

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