Plasma urate and risk of Parkinson's disease.

Plasma urate and risk of Parkinson's disease. Research Abstract Details 

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Plasma urate and risk of Parkinson's disease. Abstract Text:

M G Weisskopf,E O'Reilly,H Chen,M A Schwarzschild,A Ascherio,

Oxidative stress contributes to dopaminergic neuron degeneration in Parkinson's disease. Urate, a potent antioxidant, could be neuroprotective. To determine whether higher plasma concentrations of urate predict a reduced risk of Parkinson's disease, the authors conducted a nested case-control study among participants in the Health Professionals Follow-up Study, a cohort comprising over 18,000 men who provided blood samples in 1993-1995. Eighty-four incident cases of Parkinson's disease were diagnosed through 2000, and each was randomly matched to two controls by year of birth, race, and time of blood collection. Rate ratios of Parkinson's disease according to quartile of uricemia were estimated by use of conditional logistic regression. The mean urate concentration was 5.7 mg/dl among cases and 6.1 mg/dl among controls (p = 0.01). After adjustment for age, smoking, and caffeine, the rate ratio of Parkinson's disease for the highest quartile of uricemia compared with the lowest was 0.43 (95% confidence interval: 0.18, 1.02; p(trend) = 0.017). This association was stronger in analyses excluding cases diagnosed within 4 years (median) from blood collection (rate ratio = 0.17, 95% confidence interval: 0.04, 0.69; p(trend) = 0.010). These results suggest that high plasma urate concentrations may decrease the risk of Parkinson's disease, and they raise the possibility that interventions to increase plasma urate may reduce the risk and delay the progression of Parkinson's disease.

Plasma urate and risk of Parkinson's disease. Publishing Authors By Initials

MG Weisskopf,E O'Reilly,H Chen,MA Schwarzschild,A Ascherio,

For similar heterocyclic compounds: alkaloids: xanthines: uric acid research abstracts see: heterocyclic compounds: alkaloids: xanthines: uric acid research

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MEDLINE DATE:

Plasma urate and risk of Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: American journal of epidemiology

VOLUME: 166

Page Numbers: 561-7

Journal Abbreviation: Am. J. Epidemiol.

ISSN: 0002-9262

DAY: 20

MONTH: 06

YEAR: 2007

Plasma urate and risk of Parkinson's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7910653

Plasma urate and risk of Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: Uric Acid

MESH TERMS: blood

Chemical & Substance for Abstract: Plasma urate and risk of Parkinson's disease. Information

Substance Name: Uric Acid

Registry Number: 69-93-2

Grant and Affiliation Information for Plasma urate and risk of Parkinson's disease.

AFFILIATION: Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA. mweissko@hsph.harvard.edu

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS048517

ACRONYM: NS

MEDLINETA: Am J Epidemiol

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