Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis.

Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis. Research Abstract Details 

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Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis. Abstract Text:

Tissue factor is a cell surface protein that is expressed constitutively by monocytes, macrophages and fibroblasts, but also by some other cells in response to a variety of stimuli. The main function of the tissue factor is to form a complex with factor VII/VIIa that converts factors IX and X to their active forms. Tissue factor is also involved in the pathophysiology of systemic inflammatory disorders, coagulopathies, atherosclerotic disease, tumor angiogenesis and metastasis. Increased tissue factor expression either locally in the coronary plaques or systematically on circulating blood elements of patients with acute coronary syndromes may be responsible for increased thrombin generation, thus leading to platelet activation and fibrin formation. Tissue factor therefore plays a pivotal role in the initiation of thrombotic complications in patients with coronary artery disease.

Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis. Publishing Authors By Initials

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Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 57

Page Numbers: 1-5

Journal Abbreviation: Physiol Res

ISSN: 0862-8408

DAY: 2

MONTH: 01

YEAR: 2007

Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis. Information

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LANGUAGE: eng

NlmUniqueID: 9112413

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Grant and Affiliation Information for Plasma tissue factor in coronary artery disease: further step to the understanding of the basic mechanisms of coronary artery thrombosis.

AFFILIATION: Department Medicine I, University Hospital, Hradec Králové, Czech Republic. vojacjan@fnhk.cz.

Country: Czech Republic

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MEDLINETA: Physiol Res

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