Plasma steroid hormones in women with epithelial ovarian carcinoma.

Plasma steroid hormones in women with epithelial ovarian carcinoma. Research Abstract Details 

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Plasma steroid hormones in women with epithelial ovarian carcinoma. Abstract Text:

C G Mählck,

Plasma concentrations of steroid hormones were investigated in 51 postmenopausal or bilaterally oophorectomized women with epithelial ovarian carcinoma, but free from other malignant or endocrine disease. All FIGO stages and the histological types IC, IIC, IIIC and V are represented. Plasma levels of progesterone (P), 20 alpha-hydroxyprogesterone (20 alpha-OH-P), androstenedione (A), testosterone (T), estradiol (E2), Sex-Hormone-Binding Globulin (SHBG) and albumin were analysed, and unbound fractions of testosterone (UT) and estradiol (UE) were calculated. Blood samples were drawn for radio-immunoassay prior to and during chemotherapy at monthly intervals on four occasions. Thus, it was possible to study how plasma levels of steroid hormones are influenced by tumor volume, stage, histological type, effect of chemotherapy, recurrence of disease, and finally, whether determination of the initial plasma level of any steroid hormone, separately or in combination, may give an indication as to the prognosis of the disease. Plasma hormone levels were also compared with those of a control group of postmenopausal women (PM), a control group of fertile women in early follicular phase of the menstrual cycle (FPh), and, finally, with a control group of postmenopausal women with a non-gynecologic disseminated malignant disease (DMD). A relationship has been found between tumor volume and plasma concentration of the investigated hormones. Corresponding relationships have also been found vis-à-vis FIGO stage and histological type, though probably secondary to tumor volume. With reduction of tumor volume during treatment, a concomitant decrease in plasma concentration has been found concerning P, A and E2. The unbound fraction of T was not influenced by therapy and did not differ from PM controls. With the combined determination of P and A it has been possible to detect recurrence of disease earlier than by clinical means in the majority of cases. Certain combinations of the initial values of P, A, T and A/alb seem to predict prognosis as well as or better than does FIGO stage. In conclusion, a correlation between steroidogenesis and progress of epithelial ovarian carcinoma seems to exist. Steroidogenesis might also reflect the prognosis of the disease.

Plasma steroid hormones in women with epithelial ovarian carcinoma. Publishing Authors By Initials

CG Mählck,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Plasma steroid hormones in women with epithelial ovarian carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta obstetricia et gynecologica Scandinavica. Sup

VOLUME: 137

Page Numbers: 1-31

Journal Abbreviation:

ISSN: 0300-8835

DAY: 21

MONTH: 02

YEAR: 1986

Plasma steroid hormones in women with epithelial ovarian carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 337655

Plasma steroid hormones in women with epithelial ovarian carcinoma. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: therapy

Chemical & Substance for Abstract: Plasma steroid hormones in women with epithelial ovarian carcinoma. Information

Substance Name: Gonadal Steroid Hormones

Registry Number: 0

Grant and Affiliation Information for Plasma steroid hormones in women with epithelial ovarian carcinoma.

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Country: SWEDEN

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MEDLINETA: Acta Obstet Gynecol Scand Supp

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