Plasma sphingosine 1-phosphate metabolism and analysis.

Plasma sphingosine 1-phosphate metabolism and analysis. Research Abstract Details 

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Plasma sphingosine 1-phosphate metabolism and analysis. Abstract Text:

The importance of sphingosine 1-phosphate (Sph-1-P) as an intercellular sphingolipid mediator has been established in various systems, and this is especially true in the areas of vascular biology and immunology. Blood platelets store Sph-1-P abundantly and release this bioactive lysophospholipid extracellularly upon stimulation, while vascular endothelial cells and smooth muscle cells respond dramatically to this platelet-derived bioactive lipid. Most of the responses elicited by extracellular Sph-1-P are believed to be mediated by G protein-coupled cell surface receptors, i.e., S1Ps. It is likely that regulation of Sph-1-P biological activity could be important for therapeutics, including but not limited to control of vascular disorders. Furthermore, elucidation of the mechanisms by which the levels of Sph-1-P in the blood are regulated seems important. Accordingly, the application of Sph-1-P analysis to laboratory medicine may be an important task in clinical medicine. In this review, Sph-1-P-related metabolism in the plasma will be summarized. Briefly, the levels and bioactivities of plasma Sph-1-P in vivo may be regulated by various factors, including Sph-1-P release from platelets (and red blood cells, based upon the recent reports), Sph-1-P distribution between albumin and lipoproteins, and S1P expression and lipid phosphate phosphatase activity on the cell surface. Then, application of Sph-1-P analysis to laboratory medicine will be discussed.

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Plasma sphingosine 1-phosphate metabolism and analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochimica et biophysica acta

VOLUME: 1780

Page Numbers: 606-11

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 22

MONTH: 10

YEAR: 2007

Plasma sphingosine 1-phosphate metabolism and analysis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Plasma sphingosine 1-phosphate metabolism and analysis.

AFFILIATION: Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Country: Netherlands

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MEDLINETA: Biochim Biophys Acta

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