Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo.

Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Research Abstract Details 

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Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Abstract Text:

Robin P F Dullaart,Geesje M Dallinga-Thie,Arie van Tol,Robin P F Dullaart,Geesje M Dallinga-Thie,Arie van Tol,

OBJECTIVE: Phospholipid transfer protein (PLTP) is an important regulator in the transport of surface components of triglyceride-rich lipoprotein (TRL) to high density lipoprotein (HDL) during lipolysis and may therefore play an important role in regulating HDL transport. In this study we investigated the relationship of plasma PLTP activity with HDL metabolism in men. DESIGN AND METHODS: The kinetics of HDL LpA-I and LpA-I:A-II were measured using intravenous administration of [D3]-leucine, gas chromatography-mass spectrometry (GCMS) and a new multicompartmental model for HDL subpopulation kinetics (SAAM II) in 31 men with wide-ranging body mass index (BMI 18-46 kg/m2). Plasma PLTP activity was determined as the transfer of radiolabelled phosphatidylcholine from small unilamellar phosphatidylcholine vesicles to ultracentrifugally isolated HDL. RESULTS: PLTP activity was inversely associated with LpA-I concentration and production rate (PR) after adjusting for insulin resistance (P < 0.05). No significant associations were observed between plasma PLTP activity and LpA-I fractional catabolic rate (FCR). In multivariate analysis, including homeostasis model assessment score (HOMA), triglyceride, cholesteryl ester transfer protein (CETP) activity and PLTP activity, PLTP activity was the only significant determinant of LpA-I concentration and PR (P = 0.020 and P = 0.016, respectively). CONCLUSIONS: Plasma PLTP activity may be a significant, independent determinant of LpA-I kinetics in men, and may contribute to the maintenance of the plasma concentration of these lipoprotein particles in setting of hypercatabolism of HDL.

Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Publishing Authors By Initials

RP Dullaart,GM Dallinga-Thie,A van Tol,RP Dullaart,GM Dallinga-Thie,A van Tol,

For similar proteins: carrier proteins: phospholipid transfer proteins research abstracts see: proteins: carrier proteins: phospholipid transfer proteins research

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Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical endocrinology

VOLUME: 65

Page Numbers: 752-9

Journal Abbreviation: Clin. Endocrinol. (Oxf)

ISSN: 0300-0664

DAY: 3

MONTH: Dec

YEAR: 2006

Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 346653

Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Keywords Mesh Terms:

KEYWORDS: Phospholipid Transfer Proteins

MESH TERMS: blood

Chemical & Substance for Abstract: Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo. Information

Substance Name: Leucine

Registry Number: 61-90-5

Grant and Affiliation Information for Plasma phospholipid transfer protein activity, a determinant of HDL kinetics in vivo.

AFFILIATION: Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, WA, Australia.

Country: England

AGENCY: United States NIBIB

GRANT: P41 EB-001975

ACRONYM: EB

MEDLINETA: Clin Endocrinol (Oxf)

REFSOURCE: Clin Endocrinol (Oxf). 2007 Aug;67(2):31

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