Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study.

Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Research Abstract Details 

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Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Abstract Text:

BACKGROUND: Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia. OBJECTIVE: To determine whether plasma phosphatidylcholine (PC) DHA content is associated with the risk of developing dementia. Design, Setting, and PARTICIPANTS: A prospective follow-up study in 899 men and women who were free of dementia at baseline, had a median age of 76.0 years, and were followed up for a mean of 9.1 years for the development of all-cause dementia and Alzheimer disease. MAIN OUTCOME MEASURES: Plasma PC fatty acid levels were measured at baseline. Cox proportional regression analysis was used to assess relative risks of all-cause dementia and Alzheimer disease according to baseline plasma levels. RESULTS: Ninety-nine new cases of dementia (including 71 of Alzheimer disease) occurred during the follow-up. After adjustment for age, sex, apolipoprotein E epsilon4 allele, plasma homocysteine concentration, and education level, subjects in the upper quartile of baseline plasma PC DHA levels, compared with subjects in the lower 3 quartiles, had a relative risk of 0.53 of developing all-cause dementia (95% confidence interval, 0.29-0.97; P=.04) and 0.61 of developing Alzheimer disease (95% confidence interval, 0.31-1.18; P=.14). Subjects in the upper quartile of plasma PC DHA levels had a mean DHA intake of 0.18 g/d and a mean fish intake of 3.0 servings per week (P<.001) in a subset of 488 participants. We found no other significant associations. CONCLUSION: The top quartile of plasma PC DHA level was associated with a significant 47% reduction in the risk of developing all-cause dementia in the Framingham Heart Study.

Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk research

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Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of neurology

VOLUME: 63

Page Numbers: 1545-50

Journal Abbreviation: Arch. Neurol.

ISSN: 0003-9942

DAY: 3

MONTH: Nov

YEAR: 2006

Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372436

Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Keywords Mesh Terms:

KEYWORDS: Risk

MESH TERMS: blood

Chemical & Substance for Abstract: Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Information

Substance Name: Docosahexaenoic Acids

Registry Number: 25167-62-8

Grant and Affiliation Information for Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study.

AFFILIATION: Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition REsearch Center on Aging, Tuffs University, Boston, MA 02111, USA. ernst.schaefer@tufts.edu

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HC-25195

ACRONYM: HC

MEDLINETA: Arch Neurol

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