Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects.

Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Research Abstract Details 

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Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Abstract Text:

J Tong,K M Utzschneider,D B Carr,S Zraika,J Udayasankar,F Gerchman,R H Knopp,S E Kahn,

AIMS/HYPOTHESIS: Pancreatic polypeptide (PP) is produced by the F-cells of the pancreas, and its plasma concentration has been used as a marker of parasympathetic activity. Recent work in rodents suggests that there is both sympathetic and parasympathetic innervation of white adipose tissue and that parasympathetic activity is anabolic resulting in lipid accumulation. We have examined whether in humans increased PP levels are associated with increased intra-abdominal fat (IAF), and thereby insulin resistance. MATERIALS AND METHODS: We measured PP levels in 177 non-diabetic subjects (75 male/102 female; age 32-75 years) 3 min after an i.v. glucose bolus during a frequently sampled intravenous glucose tolerance test. IAF and s.c. fat (SCF) areas were measured by CT scan. The insulin sensitivity index (S (I)) was quantified using Bergman's minimal model. RESULTS: PP levels were higher in men than in women (96.2 +/- 72.2 vs 76.1 +/- 55.0 pg/ml, mean +/- SD, p = 0.037), as was IAF area (124.7 +/- 67.4 vs 83.0 +/- 57.7 cm(2), p < 0.001). While PP levels were significantly associated with IAF (r = 0.16, p = 0.031), WHR (r = 0.30, p < 0.001) and age (r = 0.37, p < 0.01), they were not associated with SCF (r = 0.02, p = 0.829). The association between PP and IAF was not independent of age and/or sex. S(I) was negatively associated with PP levels (r = -0.17, p = 0.026) and IAF area (r = -0.65, p < 0.001). The association between S(I) and PP disappeared after adjusting for IAF area, indicating that S(I) was not a major determinant of PP levels. CONCLUSIONS/INTERPRETATION: In humans, age and sex may modulate the association between plasma PP level and IAF area, suggesting that they may be determinants of parasympathetic activity and thus IAF accumulation.

Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Publishing Authors By Initials

J Tong,KM Utzschneider,DB Carr,S Zraika,J Udayasankar,F Gerchman,RH Knopp,SE Kahn,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pancreatic hormones: pancreatic polypeptide research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pancreatic hormones: pancreatic polypeptide research

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Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Diabetologia

VOLUME: 50

Page Numbers: 439-42

Journal Abbreviation: Diabetologia

ISSN: 0012-186X

DAY: 15

MONTH: 12

YEAR: 2006

Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Information

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LANGUAGE: eng

NlmUniqueID: 6777

Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Keywords Mesh Terms:

KEYWORDS: Pancreatic Polypeptide

MESH TERMS: blood

Chemical & Substance for Abstract: Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Information

Substance Name: Pancreatic Polypeptide

Registry Number: 59763-91-6

Grant and Affiliation Information for Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects.

AFFILIATION: Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA. tongj@u.washington.edu

Country: Germany

AGENCY: United States NHLBI

GRANT: HL-30086

ACRONYM: HL

MEDLINETA: Diabetologia

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