Plasma levels, psychophysiological variables, and clinical response to amitriptyline.

Plasma levels, psychophysiological variables, and clinical response to amitriptyline. Research Abstract Details 

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Plasma levels, psychophysiological variables, and clinical response to amitriptyline. Abstract Text:

Hamilton depression scale ratings and physiological measurements were made for 37 patients with primary depression before treatment with amitriptyline (150 mg/day) and again after 2 and 4 weeks of treatment; plasma drug levels were determined weekly. Improvement was maximal at mean amitriptyline + nortriptyline concentrations of 125-200 ng/ml (14 patients), while at lower levels the outcome was significantly poorer (12 patients). Highly variable results were seen in 11 patients with levels between 200 and 301 ng/ml, with lesser improvement occurring in those patients who exhibited poor habituation of the skin resistance response before treatment. Other psychophysiological variables showed significant changes during treatment, but no correlation with clinical results or drug levels.

Plasma levels, psychophysiological variables, and clinical response to amitriptyline. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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Plasma levels, psychophysiological variables, and clinical response to amitriptyline. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 6

Page Numbers: 223-34

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Apr

YEAR: 1982

Plasma levels, psychophysiological variables, and clinical response to amitriptyline. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Plasma levels, psychophysiological variables, and clinical response to amitriptyline. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: blood

Chemical & Substance for Abstract: Plasma levels, psychophysiological variables, and clinical response to amitriptyline. Information

Substance Name: Nortriptyline

Registry Number: 72-69-5

Grant and Affiliation Information for Plasma levels, psychophysiological variables, and clinical response to amitriptyline.

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Country: NETHERLANDS

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MEDLINETA: Psychiatry Res

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