Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage.

Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. Research Abstract Details 

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Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. Abstract Text:

Veli-Matti Ulander,Vedran Stefanovic,Junko Masuda,Kimihiro Suzuki,Vilho Hiilesmaa,Risto Kaaja,

INTRODUCTION: The presence of antiphospholipid (aPL) antibodies increases the risk for recurrent miscarriage (RM). Annexins are a family of structurally related proteins which all bind to anionic phospholipids (PLs) preventing clotting on vascular phospholipid surfaces. The aim of our study was to define plasma concentrations of circulating annexins IV and V at the beginning of pregnancy among women with a history of RM, and in connection to their aPL antibody status. MATERIALS AND METHODS: Sixty-eight women with RM and 25 controls without history of adverse pregnancy outcome were included in the study. Concentrations of annexins IV and V in plasma were determined by using a sandwich ELISA technique. RESULTS: Hereditary or acquired thrombophilic disorders were found in 53% (36/68) of the patients with RM. Plasma levels of annexin V were significantly higher at the beginning of pregnancy (P=0.03), at the 6th (P=0.01) and 8th week of pregnancy in women with aPL antibodies compared with those without aPL antibodies. A tendency towards higher plasma levels of annexin V was observed in those whose pregnancies ended in miscarriage compared with those with successful pregnancy, although the results did not reach statistical significance (P=0.10). Plasma levels of annexin IV at the first visit in women with aPL antibodies were similar to those at 6 and 8 weeks of gestation. There were no significant differences in plasma annexin IV levels between women with and without aPL antibodies. CONCLUSIONS: Patients with RM show elevated plasma levels of annexin V in presence of aPL antibodies. These antibodies could displace annexin from anionic phospholipid surfaces of syncytiotrophoblasts (STBs) and hereby promote coagulation activation.

Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. Publishing Authors By Initials

VM Ulander,V Stefanovic,J Masuda,K Suzuki,V Hiilesmaa,R Kaaja,

For similar hemic and lymphatic diseases: hematologic diseases: thrombophilia research abstracts see: hemic and lymphatic diseases: hematologic diseases: thrombophilia research

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Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Thrombosis research

VOLUME: 120

Page Numbers: 865-70

Journal Abbreviation: Thromb. Res.

ISSN: 0049-3848

DAY: 23

MONTH: 03

YEAR: 2007

Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. Information

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LANGUAGE: eng

NlmUniqueID: 326377

Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. Keywords Mesh Terms:

KEYWORDS: Thrombophilia

MESH TERMS: immunology

Chemical & Substance for Abstract: Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage. Information

Substance Name: Antibodies, Antiphospholipid

Registry Number: 0

Grant and Affiliation Information for Plasma levels of annexins IV and V in relation to antiphospholipid antibody status in women with a history of recurrent miscarriage.

AFFILIATION: Department of Obstetrics and Gynaecology, Helsinki University Hospital, Haartmaninkatu 2, 00290 Helsinki, Finland.

Country: United States

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MEDLINETA: Thromb Res

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