Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension.

Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension. Research Abstract Details 

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Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension. Abstract Text:

K Hashizume,T Ogihara,A Yamatodani,T Yamamoto,H Wada,Y Kumahara,

Two isomers of dopamine sulfate, dopamine 3-O-sulfate(3-O-S) and dopamine 4-O-sulfate(4-O-S), in the plasma and urine of patients with essential hypertension and normotensive controls were measured by HPLC-fluorometry. The plasma level of 3-O-S was significantly higher in patients with essential hypertension than in normotensive controls (20.9 +/- 2.2 pmol/ml and 16.3 +/- 1.4 pmol/ml respectively, p less than 0.05) and the plasma levels of 4-O-S were slightly increased in hypertensive patients. The plasma level of 3-O-S was correlated with the serum level of creatinine in both normotensives and hypertensives. In hypertensives, the plasma level of 3-O-S was also correlated with that of noradrenaline. However the creatinine clearances were similar in the two groups, the urinary clearance of 3-O-S was slightly lower in patients with essential hypertension than in normotensive controls. These data indicate that the plasma level of 3-O-S is elevated in essential hypertension because of the abnormality in dopaminergic metabolism and renal disturbance in its excretion.

Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension. Publishing Authors By Initials

K Hashizume,T Ogihara,A Yamatodani,T Yamamoto,H Wada,Y Kumahara,

For similar organic chemicals: alcohols: amino alcohols: ethanolamines: norepinephrine research abstracts see: organic chemicals: alcohols: amino alcohols: ethanolamines: norepinephrine research

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Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 10

Page Numbers: 561-74

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1988

Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension. Keywords Mesh Terms:

KEYWORDS: Norepinephrine

MESH TERMS: metabolism

Chemical & Substance for Abstract: Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension.

AFFILIATION: Department of Medicine & Geriatrics, Osaka University Medical School, Japan.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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