Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study.

Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. Abstract Text:

P L Lutsey,M Cushman,L M Steffen,D Green,R G Barr,D Herrington,P Ouyang,A R Folsom,

BACKGROUND: Hemostatic factors and endothelial markers may play some role in racial/ethnic differences in cardiovascular disease (CVD) rates. However, little information exists on hemostatic factors and endothelial markers across racial/ethnic groups. OBJECTIVES: To describe, in four American racial/ethnic groups (Caucasian, Black, Hispanic, and Chinese), mean levels of selected hemostatic factors and endothelial markers. PATIENTS AND METHODS: Multi-ethnic Study of Atherosclerosis baseline data were used (participant age: 45-84 years). Sex-specific analysis of covariance models, and t-tests for pairwise comparisons, were used to compare means of factors and markers. Adjustments were made for demographics and traditional CVD risk factors. Differences were significant at P < 0.05. RESULTS: Blacks had the highest levels of factor VIII, D-Dimer, plasmin-antiplasmin (PAP), and von Willebrand factor, among the highest levels of fibrinogen and E-selectin (women only), but among the lowest levels of intercellular adhesion molecule 1 (ICAM-1), and, in men, the lowest levels of plasminogen activator inhibitor-1 (PAI-1). Whites and Hispanics tended to have intermediate levels of factors and markers, although they had the highest levels of ICAM-1, and Hispanics had the highest mean levels of fibrinogen and E-selectin (women only). Chinese participants had among the highest levels of PAI-1, but the lowest, or among the lowest, of all other factors and markers. No soluble thrombomodulin differences were observed. CONCLUSIONS: In this large cohort, hemostatic factor and endothelial marker mean levels varied by race/ethnicity, even after adjustment for traditional CVD risk factors.

Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. Publishing Authors By Initials

PL Lutsey,M Cushman,LM Steffen,D Green,RG Barr,D Herrington,P Ouyang,AR Folsom,

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

PUBMED ID PMID:

MEDLINE DATE:

Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of thrombosis and haemostasis : JTH

VOLUME: 4

Page Numbers: 2629-35

Journal Abbreviation: J. Thromb. Haemost.

ISSN: 1538-7933

DAY: 26

MONTH: 09

YEAR: 2006

Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101170508

Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study. Information

Substance Name: Blood Coagulation Factors

Registry Number: 0

Grant and Affiliation Information for Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study.

AFFILIATION: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.

Country: England

AGENCY: United States NHLBI

GRANT: N01-HC-95166

ACRONYM: HC

MEDLINETA: J Thromb Haemost

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study Related Publications

• A national survey of home-based care kits for palliative HIV/AIDS care in South Africa.
• ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE).
• Ankle brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohort.
• Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults.
• Associations of acculturation and socioeconomic status with subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis.
• Associations of psychosocial factors with heart rate and its short-term variability: multi-ethnic study of atherosclerosis.
• Chronic kidney disease increases risk for venous thromboembolism.
• Female breast cancer incidence and survival in Utah according to religious preference, 1985-1999.
• HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study.
• HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study.
• Homocysteine and venous thromboembolism in LITE.
• Lack of association between uncoupling protein-2 Ala55Val polymorphism and incident diabetes in the atherosclerosis risk in communities study.
• Medical center improves conscious sedation policy.
• NSAID use and survival after breast cancer diagnosis in post-menopausal women.
• Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa women's health study.
• Pancreatic cancer incidence in relation to female reproductive factors: Iowa Women's Health Study.
• Pathology quiz case 1. Colloid milia.
• Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study.
• Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study.
• Race-gender differences in the association of trait anger with subclinical carotid artery atherosclerosis: the Atherosclerosis Risk in Communities Study.
• Regional family patterns; the New England family.
• Reproductive characteristics and risk of kidney cancer: Iowa Women's Health Study.
• Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE).
• The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study.
• The metabolic syndrome is associated with reduced risk of prostate cancer.
• Understanding the relative influence of neighborhood, family, and youth on adolescent drug use.
• Variability of myocardial blood flow measurements by magnetic resonance imaging in the multi-ethnic study of atherosclerosis.