Plasma glucose and the action of calorie restriction on aging.

Plasma glucose and the action of calorie restriction on aging. Research Abstract Details 

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Plasma glucose and the action of calorie restriction on aging. Abstract Text:

Roger McCarter,Walter Mejia,Yuji Ikeno,Vincent Monnier,Kristen Kewitt,Michael Gibbs,Alex McMahan,Randy Strong,Roger McCarter,Walter Mejia,Yuji Ikeno,Vincent Monnier,Kristen Kewitt,Michael Gibbs,Alex McMahan,Randy Strong,

We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6 mice expressing a human GLUT4 minigene (transgenic [TG] mice) and their nontransgenic littermates (NTG mice) were maintained under specific pathogen-free conditions. Mice were fed ad libitum (A mice) or 40% less than ad libitum (R mice) from age 6 weeks. Over the life span there were three different levels of plasma glucose, with NTGA mice having the highest daily levels, TGR mice the lowest daily values, and TGA and NTGR mice having similar levels intermediate between these values. Despite differences in plasma glucose, the differences measured in longevity (50% and 10% survival), physiology and tissue pathology were associated with diet rather than with levels of plasma glucose. We conclude that decreased plasma glucose over the life span is not an important factor in the action of calorie restriction on aging processes.

Plasma glucose and the action of calorie restriction on aging. Publishing Authors By Initials

R McCarter,W Mejia,Y Ikeno,V Monnier,K Kewitt,M Gibbs,A McMahan,R Strong,R McCarter,W Mejia,Y Ikeno,V Monnier,K Kewitt,M Gibbs,A McMahan,R Strong,

For similar behavior and behavior mechanisms: behavior: motor activity research abstracts see: behavior and behavior mechanisms: behavior: motor activity research

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Plasma glucose and the action of calorie restriction on aging. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The journals of gerontology. Series A, Biological

VOLUME: 62

Page Numbers: 1059-70

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 20

MONTH: Oct

YEAR: 2007

Plasma glucose and the action of calorie restriction on aging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502837

Plasma glucose and the action of calorie restriction on aging. Keywords Mesh Terms:

KEYWORDS: Motor Activity

MESH TERMS: physiology

Chemical & Substance for Abstract: Plasma glucose and the action of calorie restriction on aging. Information

Substance Name: Blood Glucose

Registry Number: 0

Grant and Affiliation Information for Plasma glucose and the action of calorie restriction on aging.

AFFILIATION: The Pennsylvania State University, Center for Developmental and Health Genetics, Gardner House, University Park, PA 16802, USA. rjm28@psu.edu

Country: United States

AGENCY: United States NIA

GRANT: P01 AG-14674

ACRONYM: AG

MEDLINETA: J Gerontol A Biol Sci Med Sci

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