Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test.

Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test. Research Abstract Details 

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Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test. Abstract Text:

Teruyo Kida,Tetsuya Sugiyama,Hidehiro Oku,Seiyo Harino,Tsunehiko Ikeda,Teruyo Kida,Tetsuya Sugiyama,Hidehiro Oku,Seiyo Harino,Tsunehiko Ikeda,

PURPOSE: To determine the relationship between the changes in optic nerve head (ONH) circulation and the level of plasma endothelin-1 (ET-1) during the glucose tolerance test (GTT). METHODS: Twenty-six healthy volunteers with normal GTT and 15 patients with mild hyperglycemia and abnormal GTT were studied. The ONH circulation [square blur rate (SBR) value], blood pressure, intraocular pressure (IOP), blood glucose, blood insulin and plasma ET-1 were determined before and every hour up to 3 h after an oral intake of 75 g of glucose. RESULTS: The SBR increased in the normal glucose tolerance group at all times during the GTT, but it decreased significantly in the abnormal glucose tolerance group (P < 0.05). Before the GTT, the plasma ET-1 level was not significantly different in the two groups; however, the level increased 1 h after the oral GTT in the abnormal glucose tolerance group (P < 0.05). No significant changes were observed in mean blood pressure or IOP. CONCLUSIONS: ONH circulation increased after glucose intake in the normal glucose tolerance group and remained high even after the blood glucose level had returned to its baseline. The decrease in ONH circulation in the abnormal glucose tolerance group was attributed partly to the increased ET-1.

Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test. Publishing Authors By Initials

T Kida,T Sugiyama,H Oku,S Harino,T Ikeda,T Kida,T Sugiyama,H Oku,S Harino,T Ikeda,

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Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Graefe's archive for clinical and experimental oph

VOLUME: 245

Page Numbers: 1289-93

Journal Abbreviation: Graefes Arch. Clin. Exp. Ophth

ISSN: 0721-832X

DAY: 17

MONTH: 01

YEAR: 2007

Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test. Information

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LANGUAGE: eng

NlmUniqueID: 8205248

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Grant and Affiliation Information for Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test.

AFFILIATION: Department of Ophthalmology, Osaka Medical College, Osaka, Japan. kidateruyo@yahoo.com

Country: Germany

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MEDLINETA: Graefes Arch Clin Exp Ophthalm

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