Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia.

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Research Abstract Details 

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Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Abstract Text:

John G Csernansky,Hongxin Dong,Anne M Fagan,Lei Wang,Chengjie Xiong,David M Holtzman,John C Morris,

OBJECTIVE: Studies of subjects with dementia of the Alzheimer type have reported correlations between increases in activity of the hypothalamic-pituitary-adrenal (HPA) axis and hippocampal degeneration. In this study, the authors sought to determine whether increases in plasma cortisol, a marker of HPA activity, were associated with clinical and cognitive measures of the rate of disease progression in subjects with Alzheimer-type dementia. METHOD: Thirty-three subjects with very mild and mild Alzheimer-type dementia and 21 subjects without dementia were assessed annually for up to 4 years with the Clinical Dementia Rating scale and a battery of neuropsychological tests. Plasma was obtained at 8 a.m. on a single day and assayed for cortisol. Rates of change over time in the clinical and cognitive measures were derived from growth curve models. RESULTS: In the subjects with dementia, but not in those without dementia, higher plasma cortisol levels were associated with more rapidly increasing symptoms of dementia and more rapidly decreasing performance on neuropsychological tests associated with temporal lobe function. No associations were observed between plasma cortisol levels and clinical and cognitive assessments obtained at the single assessment closest in time to the plasma collection. CONCLUSIONS: Higher HPA activity, as reflected by increased plasma cortisol levels, is associated with more rapid disease progression in subjects with Alzheimer-type dementia.

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Publishing Authors By Initials

JG Csernansky,H Dong,AM Fagan,L Wang,C Xiong,DM Holtzman,JC Morris,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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MEDLINE DATE:

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of psychiatry

VOLUME: 163

Page Numbers: 2164-9

Journal Abbreviation:

ISSN: 0002-953X

DAY: 3

MONTH: Dec

YEAR: 2006

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370512

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: statistics & numerical data

Chemical & Substance for Abstract: Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Information

Substance Name: Hydrocortisone

Registry Number: 50-23-7

Grant and Affiliation Information for Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia.

AFFILIATION: Alzheimer's Disease Research Center and the Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. jgc@conte.wustl.edu

Country: United States

AGENCY: United States NIA

GRANT: R01 AG025824-01

ACRONYM: AG

MEDLINETA: Am J Psychiatry

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