Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets.

Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets. Research Abstract Details 

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Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets. Abstract Text:

Comparative plasma concentrations of morphine in two children with chronic pain who received controlled-release and regular morphine sulphate tablets are described. The controlled-release tablets were given every 12 h and regular tablets every 4 h. At steady-state, the maximum morphine plasma concentration (Cmax) was 24.1 ng/ml at 45 mg and 18.7 ng/ml at 30 mg of controlled-release morphine sulphate tablets. The Cmax was 17.6 ng/ml at 15 mg and 31.4 ng/ml at 20 mg dose of the regular tablets. The maximum concentration occurred at 2.0 and 2.5 h after controlled-release and 0.25 and 1.5 h after regular tablets. The minimum morphine plasma concentrations and the area under the plasma concentration-time curve normalized for dose were comparable for the controlled-release and regular tablets. These data indicate that controlled-release morphine sulphate may be well absorbed in relation to the regular tablets. If these results are confirmed in a large group of patients, the controlled-release morphine sulphate tablets may offer a convenient (less frequent) dosing compared with regular tablets in children suffering from chronic pain due to malignancy.

Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets. Publishing Authors By Initials

For similar pharmaceutical preparations: dosage forms: tablets research abstracts see: pharmaceutical preparations: dosage forms: tablets research

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Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 16

Page Numbers: 193-5

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Jun

YEAR: 1991

Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets. Information

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LANGUAGE: eng

NlmUniqueID: 8704308

Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets. Keywords Mesh Terms:

KEYWORDS: Tablets

MESH TERMS: etiology

Chemical & Substance for Abstract: Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets. Information

Substance Name: Morphine

Registry Number: 57-27-2

Grant and Affiliation Information for Plasma concentrations of morphine in children with chronic pain--comparison of controlled release and regular morphine sulphate tablets.

AFFILIATION: College of Pharmacy and Medicine, Ohio State University, Columbus 43210.

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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