Plaque rupture model in mice.

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Plaque rupture model in mice. Abstract Text:

Takeshi Sasaki,Kae Nakamura,Masafumi Kuzuya,

It is widely believed that rupture of a vulnerable atherosclerotic plaque leads to acute coronary events and stroke. However, the exact mechanisms involved in the plaque rupture remain unknown. Pathological animal models are valuable in the research on human disease mechanism, their therapy, and drug development. Recently, we have proposed a novel murine model of atherosclerotic plaque rupture associated with not only intraplaque hemorrhage but also luminal thrombus using combination treatments of ligation and perivascular cuff placement on the carotid artery.

Plaque rupture model in mice. Publishing Authors By Initials

T Sasaki,K Nakamura,M Kuzuya,

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Plaque rupture model in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Methods in molecular medicine

VOLUME: 139

Page Numbers: 67-76

Journal Abbreviation: Methods Mol. Med.

ISSN: 1543-1894

DAY: 21

MONTH: 02

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101123138

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Country: United States

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