Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.

Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. Research Abstract Details 

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Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. Abstract Text:

Yu-Li Lin,Yu-Chih Liang,Bor-Luen Chiang,Yu-Li Lin,Yu-Chih Liang,Bor-Luen Chiang,Yu-Li Lin,Yu-Chih Liang,Bor-Luen Chiang,

Placental growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF) family and represents a key regulator of angiogenic events in development and pathologic conditions. In this study, PlGF-modulated differentiation and maturation of human dendritic cells (DCs) from CD14+ monocytes were investigated. The DC, differentiated from CD14+ monocytes in the presence of PlGF during 5 days, was referred to as "PlGF-DC", in contrast to the "classical-DC", obtained in the absence of PlGF. Treatment of PlGF-DC or classical-DC with PlGF resulted in the down-regulation of CD80, CD86, CD83, CD40, and HLA-DR expression, and CD1a was increased, as well as the inhibition of IL-12 p70, p40, IL-8, and TNF-alpha production in response to LPS stimulation. This PlGF-induced DC dysfunction was recovered by anti-human VEGF receptor 1 mAb. In addition, treatment of PlGF-DC or classical-DC with PlGF resulted in the suppression of naïve CD4+ T cell proliferation in an allogenic MLR but up-regulated the IL-5 and IL-13 secretion of the CD4+ T cell. PlGF was also able to inhibit LPS-induced IkappaBalpha phosphorylation and NF-kappaB activity. Taken together, our data demonstrate that the immunosuppressive properties of PlGF are through the NF-kappaB signaling pathway. PlGF might play a major role in the pathogenesis of tumors and act as an effector molecule to skew T cell response to the Th2 phenotype, which might be more beneficial for pregnancy.

Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. Publishing Authors By Initials

YL Lin,YC Liang,BL Chiang,YL Lin,YC Liang,BL Chiang,YL Lin,YC Liang,BL Chiang,

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Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of leukocyte biology

VOLUME: 82

Page Numbers: 1473-80

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 30

MONTH: 08

YEAR: 2007

Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.

AFFILIATION: National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan, R.O.C. gicmbor@ntu.edu.tw.

Country: United States

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MEDLINETA: J Leukoc Biol

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