Placental Expression of Soluble fms-Like Tyrosine Kinase 1 is Increased in Singletons and Twin Pregnancies with Intrauterine Growth Restriction.

Placental Expression of Soluble fms-Like Tyrosine Kinase 1 is Increased in Singletons and Twin Pregnancies with Intrauterine Growth Restriction. Research Abstract Details 

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Placental Expression of Soluble fms-Like Tyrosine Kinase 1 is Increased in Singletons and Twin Pregnancies with Intrauterine Growth Restriction. Abstract Text:

Ori Nevo,Ariel Many,Jing Xu,John Kingdom,Ettore Piccoli,Stacy Zamudio,Martin Post,Alan Bocking,Tullia Todros,Isabella Caniggia,Ori Nevo,Ariel Many,Jing Xu,John Kingdom,Ettore Piccoli,Stacy Zamudio,Martin Post,Alan Bocking,Tullia Todros,Isabella Caniggia,

Objective: Intrauterine growth restriction (IUGR) is characterized by decreased placental perfusion. Low oxygen has been shown to increase soluble fms-like tyrosine kinase 1 (sFlt-1) expression in the human placenta. The objective of this study was to examine sFlt-1 expression in different types of IUGR pregnancies, including early-onset severe cases characterized by abnormal umbilical and uterine artery Doppler and discordant IUGR twins in which the normal cotwin represents the optimal control because both placentas share the same uterine environment. Patients: Placentas from four subgroups were collected: early severe IUGR with umbilical artery absent end diastolic flow (n = 19), small for gestational age with normal uterine and umbilical artery Doppler (n = 11), severely growth-restricted dichorionic and monochorionic twins with abnormal umbilical artery Doppler (n = 9), preeclamptic twins (n = 3), and age-matched normal singletons (n = 19) and twin controls (n = 8). Results: Expression of sFlt-1 mRNA and protein was significantly increased in IUGR placentas compared with small for gestational age and normal control placentas. sFlt-1 expression levels were also significantly greater in the small IUGR twin placentas from discordant twin pregnancies compared with the normal cotwin. In preeclamptic twins, sFlt-1 expression was increased in only one of the two placentas. Conclusions: Our results demonstrate that sFlt-1 expression is increased in severe IUGR placentas with abnormal umbilical artery Doppler of singletons and also in discordant IUGR twins. Reduced placental perfusion may contribute to the increased expression of sFlt-1 in IUGR pregnancies. Our data are compatible with differential sFlt-1 expression in placentas from discordant twins.

Placental Expression of Soluble fms-Like Tyrosine Kinase 1 is Increased in Singletons and Twin Pregnancies with Intrauterine Growth Restriction. Publishing Authors By Initials

O Nevo,A Many,J Xu,J Kingdom,E Piccoli,S Zamudio,M Post,A Bocking,T Todros,I Caniggia,O Nevo,A Many,J Xu,J Kingdom,E Piccoli,S Zamudio,M Post,A Bocking,T Todros,I Caniggia,

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Placental Expression of Soluble fms-Like Tyrosine Kinase 1 is Increased in Singletons and Twin Pregnancies with Intrauterine Growth Restriction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 93

Page Numbers: 285-92

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 23

MONTH: 10

YEAR: 2007

Placental Expression of Soluble fms-Like Tyrosine Kinase 1 is Increased in Singletons and Twin Pregnancies with Intrauterine Growth Restriction. Information

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LANGUAGE: eng

NlmUniqueID: 375362

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AFFILIATION: Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 600 University Avenue, Room 871C, Toronto, Ontario, Canada M5G 1X5. caniggia@mshri.on.ca.

Country: United States

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MEDLINETA: J Clin Endocrinol Metab

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