Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks.

Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Research Abstract Details 

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Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Abstract Text:

E Kinnunen,T Erkinjuntti,M Färkkilä,H Palomäki,J Porras,H Teirmaa,Y Freudenthal,P Andersson,

Sixty-one patients, 16 with classic and 45 with common migraine, were treated during three subsequent attacks with pirprofen, a new inhibitor of prostaglandin synthesis; an ergotamine tartrate compound; or placebo, in a randomized, double-blind multicentre study. Pain relief after a single dose and reduction of the attack intensity occurred most often with pirprofen in patients who needed more than one dose. Among them, however, the duration of attack was shortest with ergotamine. Working ability was well preserved with pirprofen, especially among patients with common migraine, and this treatment was ranked highest by the patients. However, no statistically significant differences were found between pirprofen and ergotamine. No serious side effects were observed with pirprofen. This study establishes the usefulness of pirprofen in the treatment of acute migraine.

Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Publishing Authors By Initials

E Kinnunen,T Erkinjuntti,M Färkkilä,H Palomäki,J Porras,H Teirmaa,Y Freudenthal,P Andersson,

For similar pharmaceutical preparations: placebos research abstracts see: pharmaceutical preparations: placebos research

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Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Cephalalgia : an international journal of headache

VOLUME: 8

Page Numbers: 175-9

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Sep

YEAR: 1988

Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Information

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LANGUAGE: eng

NlmUniqueID: 8200710

Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Keywords Mesh Terms:

KEYWORDS: Placebos

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks. Information

Substance Name: pirprofen

Registry Number: 31793-07-4

Grant and Affiliation Information for Placebo-controlled double-blind trial of pirprofen and an ergotamine tartrate compound in migraine attacks.

AFFILIATION: Institute of Occupational Health, Helsinki, Finland.

Country: NORWAY

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MEDLINETA: Cephalalgia

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