Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers.

Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. Research Abstract Details 

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Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. Abstract Text:

Adam R Frymoyer,Michael C Rowbotham,Karin Lottrup Petersen,

In this double-blind, placebo-controlled, crossover study we compared the analgesic effect of a single oral dose of 30-mg dextromethorphan and 30-mg morphine combination (MS/DM) to 30 mg morphine (MS) alone and either placebo or 30 mg dextromethorphan (DM) on cutaneous sensitization induced by heat/capsaicin (topical) sensitization on the forearm and the brief thermal sensitization model on the thigh in 22 healthy volunteers. Outcome measures were areas of secondary hyperalgesia to brush and von Frey hair stimulation in both sensitization models and the painfulness of acute thermal noxious stimulation on the upper arm. Compared with placebo, both MS/DM and morphine had some effect on the secondary hyperalgesia and reduced the painfulness of a noxious thermal stimulus. The analgesic effect of MS/DM was not superior to that of morphine on any outcome measure. These results differ from preclinical studies with animal experimental pain models in which DM markedly potentiated the analgesic effects of opioids, but they are in accordance with recent clinical trials for chronic pain. PERSPECTIVE: Adding dextromethorphan to morphine (1:1 ratio) did not enhance analgesia on measures of experimental cutaneous sensitization and acute noxious thermal stimulation in healthy volunteers. The results differ from preclinical studies but agree with clinical trials. Human experimental models of pain and neuronal sensitization, which are responsive to oral opioids, allow efficient study of opioid combination analgesics and simplify the process for determining the optimal dose and/or dose ratio.

Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. Publishing Authors By Initials

AR Frymoyer,MC Rowbotham,KL Petersen,

For similar body regions: extremities: lower extremity: thigh research abstracts see: body regions: extremities: lower extremity: thigh research

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Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journal of pain : official journal of the Amer

VOLUME: 8

Page Numbers: 19-25

Journal Abbreviation:

ISSN: 1526-5900

DAY: 16

MONTH: 11

YEAR: 2006

Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100898657

Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. Keywords Mesh Terms:

KEYWORDS: Thigh

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. Information

Substance Name: Morphine

Registry Number: 57-27-2

Grant and Affiliation Information for Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers.

AFFILIATION: UCSF Pain Clinical Research Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94115, USA.

Country: United States

AGENCY: United States NINDS

GRANT: K24 NS02164

ACRONYM: NS

MEDLINETA: J Pain

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