Bone morphogenetic proteins (BMP) constitute a sub-group of the large transforming growth factor-beta (TGF-beta) family. They play important roles in the embryonic development of multiple structures and in adult bone modeling. We have recently isolated a novel member of the BMP family from placenta, termed PLAB. PLAB is expressed highly in placenta, but can be found upon stringent analysis in low levels in most other tissues. At the amino acid level, PLAB is most closely related to BMP-8/OP-2, another member of the BMP family. Like TGF-beta, PLAB inhibits the proliferation of primitive hematopoietic progenitors. The high expression of PLAB by placenta raises the possibility that it may be a mediator of placental control of embryonic development.
PLAB, a novel placental bone morphogenetic protein. Publishing Authors By Initials
PLAB, a novel placental bone morphogenetic protein. Journal Published:
PUBLICATION TYPE: Journal Article
Journal: Biochimica et biophysica acta
VOLUME: 1354
Page Numbers: 40-4
Journal Abbreviation: Biochim. Biophys. Acta
ISSN: 0006-3002
DAY: 9
MONTH: Oct
YEAR: 1997
PLAB, a novel placental bone morphogenetic protein. Information
Number of References:
LANGUAGE: eng
NlmUniqueID: 217513
PLAB, a novel placental bone morphogenetic protein. Keywords Mesh Terms:
KEYWORDS: Transforming Growth Factor beta
MESH TERMS: physiology
Chemical & Substance for Abstract: PLAB, a novel placental bone morphogenetic protein. Information
Substance Name: growth differentiation factor 15
Registry Number: 0
Grant and Affiliation Information for PLAB, a novel placental bone morphogenetic protein.
AFFILIATION: Department of Medicine and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA. robert_hromas@iucc.iupui.edu
Country: NETHERLANDS
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MEDLINETA: Biochim Biophys Acta
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ACCESSION NUMBER: U88323
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