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PLAB, a novel placental bone morphogenetic protein.

PLAB, a novel placental bone morphogenetic protein. Research Abstract Details 

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  • PLAB, a novel placental bone morphogenetic protein. Abstract Text:

    r hromasR Hromas,m huffordM Hufford,j suttonJ Sutton,d xuD Xu,y liY Li,l luL Lu,

    Bone morphogenetic proteins (BMP) constitute a sub-group of the large transforming growth factor-beta (TGF-beta) family. They play important roles in the embryonic development of multiple structures and in adult bone modeling. We have recently isolated a novel member of the BMP family from placenta, termed PLAB. PLAB is expressed highly in placenta, but can be found upon stringent analysis in low levels in most other tissues. At the amino acid level, PLAB is most closely related to BMP-8/OP-2, another member of the BMP family. Like TGF-beta, PLAB inhibits the proliferation of primitive hematopoietic progenitors. The high expression of PLAB by placenta raises the possibility that it may be a mediator of placental control of embryonic development.

    PLAB, a novel placental bone morphogenetic protein. Publishing Authors By Initials

    r hromasR Hromas,m huffordM Hufford,j suttonJ Sutton,d xuD Xu,y liY Li,l luL Lu,

    For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

    PUBMED ID PMID:

    MEDLINE DATE:

    PLAB, a novel placental bone morphogenetic protein. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Biochimica et biophysica acta

    VOLUME: 1354

    Page Numbers: 40-4

    Journal Abbreviation: Biochim. Biophys. Acta

    ISSN: 0006-3002

    DAY: 9

    MONTH: Oct

    YEAR: 1997

    PLAB, a novel placental bone morphogenetic protein. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 217513

    PLAB, a novel placental bone morphogenetic protein. Keywords Mesh Terms:

    KEYWORDS: Transforming Growth Factor beta

    MESH TERMS: physiology

    Chemical & Substance for Abstract: PLAB, a novel placental bone morphogenetic protein. Information

    Substance Name: growth differentiation factor 15

    Registry Number: 0

    Grant and Affiliation Information for PLAB, a novel placental bone morphogenetic protein.

    AFFILIATION: Department of Medicine and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA. robert_hromas@iucc.iupui.edu

    Country: NETHERLANDS

    NETHERLANDS Research PublicationNETHERLANDS Research Publication

    AGENCY:

    GRANT:

    ACRONYM:

    MEDLINETA: Biochim Biophys Acta

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER: U88323

    Number Hits: 0

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