Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions.

Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. Research Abstract Details 

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Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. Abstract Text:

Amy H Tang,Gregory J Brunn,Marilia Cascalho,Jeffrey L Platt,

TLRs are usually thought to recognize substances produced by microorganisms and thus, to initiate host defenses. This concept, however, fails to explain some functions of this family of receptors. Recognition of endogenous substances may explain the broader functions of TLRs in physiology and disease. Activation of TLRs by endogenous substances necessitates vigorous control of the function of the receptors. This communication will summarize a line of research, which points to an endogenous agonist for TLR4 and a putative mechanism for controlling the function of that receptor.

Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. Publishing Authors By Initials

AH Tang,GJ Brunn,M Cascalho,JL Platt,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, pattern recognition: toll-like receptors research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, pattern recognition: toll-like receptors research

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Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of leukocyte biology

VOLUME: 82

Page Numbers: 282-5

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 10

MONTH: 05

YEAR: 2007

Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8405628

Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. Keywords Mesh Terms:

KEYWORDS: Toll-Like Receptors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions. Information

Substance Name: Heparitin Sulfate

Registry Number: 9050-30-0

Grant and Affiliation Information for Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions.

AFFILIATION: Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

Country: United States

AGENCY: United States PHS

GRANT: HHL079067

ACRONYM: GM

MEDLINETA: J Leukoc Biol

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