Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women.

Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women. Research Abstract Details 

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Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women. Abstract Text:

E Weiner,S J Nillius,L Wide,E D Johansson,

It has previously been reported that subdermal implants containing d-norgestrel inhibit ovulation through blockage of the positive feedback action of estrogen on luteinizing hormone (LH) release. In this study 100 micrograms of LH-releasing hormone (LRH) were injected intravenously to test the pituitary reserve capacity for gonadotrophin secretion in three women with three 40 mg d-norgestrel rods implanted subdermally for more than one year. The gonadotrophin release to LRH varied and seemed related to the ovarian steroid concentrations at the time of the LRH infusion in a manner similar to that seen during the normal menstrual cycle. It is concluded that low plasma levels of d-norgestreol do not inhibit the pituitary responsiveness to LRH. The results indicate that the blocking action of the gestagen on the positive feedback of estradiol on LH release occurs at the hypothalamus or higher CNS centers.

Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women. Publishing Authors By Initials

E Weiner,SJ Nillius,L Wide,ED Johansson,

For similar endocrine system: endocrine glands: pituitary gland: pituitary gland, anterior research abstracts see: endocrine system: endocrine glands: pituitary gland: pituitary gland, anterior research

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Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta obstetricia et gynecologica Scandinavica. Sup

VOLUME: 88

Page Numbers: 23-6

Journal Abbreviation:

ISSN: 0300-8835

DAY: 21

MONTH: 02

YEAR: 1979

Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 337655

Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women. Keywords Mesh Terms:

KEYWORDS: Pituitary Gland, Anterior

MESH TERMS: physiology

Chemical & Substance for Abstract: Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women. Information

Substance Name: Follicle Stimulating Hormone

Registry Number: 9002-68-0

Grant and Affiliation Information for Pituitary responsiveness to luteinizing hormone-releasing hormone during treatment with subdermal D-norgestrel implants in women.

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Country: SWEDEN

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MEDLINETA: Acta Obstet Gynecol Scand Supp

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