Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice.

Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice. Abstract Text:

Emma R Isaac,Nancy M Sherwood,Emma R Isaac,Nancy M Sherwood,Emma R Isaac,Nancy M Sherwood,

Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) show high mortality during the postnatal period, as well as impaired reproduction in females. This study characterizes the reproductive phenotype in female mice lacking PACAP due to targeted disruption (knockout) of the single copy pacap gene (Adcyap1) to determine the site(s) of action of PACAP in the cascade of reproductive events. PACAP null females showed normal puberty onset, estrous cycles, and seminal plugs when paired with a male of proven fertility. However, significantly fewer PACAP null females (21%) than wild-type females (100%) gave birth following mating. Although a defect was not detected in ovulation, ovarian histology or fertilization of released eggs in PACAP null females, only 13% had implanted embryos 6.5 days after mating. Associated with the decrease in implantation, prolactin and progesterone levels were significantly lower in females lacking PACAP than in wild types on day 6.5 after mating. Our evidence suggests that impaired implantation is the defect responsible for decreased fertility in PACAP null female mice.

Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice. Publishing Authors By Initials

ER Isaac,NM Sherwood,ER Isaac,NM Sherwood,ER Isaac,NM Sherwood,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular and cellular endocrinology

VOLUME: 280

Page Numbers: 13-9

Journal Abbreviation: Mol. Cell. Endocrinol.

ISSN: 0303-7207

DAY: 11

MONTH: 09

YEAR: 2007

Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7500844

Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice.

AFFILIATION: Biomedical Research Centre, University of Victoria, Victoria, B.C., Canada V8W 3N5.

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Cell Endocrinol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pituitary adenylate cyclase-activating polypeptide PACAP is important for embryo implantation in mice Related Publications

• Accomplishments in Cereal Fortification.
• Cardiac aneurysm.
• Cerebral petalias and their relationship to handedness in capuchin monkeys (Cebus apella).
• Cerebrovascular risk factors, vascular disease, and neuropsychological outcomes in adults with major depression.
• Cholinergic innervation of the frontal cortex: differences among humans, chimpanzees, and macaque monkeys.
• Comparison of water-soluble CdTe nanoparticles synthesized in air and in nitrogen.
• Correction of skeletal open bite with implant anchored molar/bicuspid intrusion.
• Effects of exercise and weight loss on depressive symptoms among men and women with hypertension.
• Evaluating strategies and costs to recruit smokeless tobacco users.
• Exercise and pharmacotherapy in the treatment of major depressive disorder.
• Experience with BGE, a naturally occurring indole compound.
• Family medicine curriculum resource project: overview.
• Fecal M2-pyruvate kinase (M2-PK): a novel marker of intestinal inflammation.
• Frequency shifting through cascaded second-order processes in a N-(4-nitrophenyl)- L-prolinol crystal.
• Gonococcic peritonitis of the upper abdomen; subcostal syndrome of Stajano; Fitz-Hugh-Curtis syndrome.
• Guest Editorial: Knowledge translation: A mandate for Federal research agencies.
• Is the obesity epidemic exaggerated? No.
• Linear electro-optic effect in the organic crystal 4-aminobenzophenone.
• Long-term cardio-respiratory consequences of heart disease in childhood.
• Needleguard systems: an evaluation.
• Obituary: jospeh L. Henderson (1903-2007).
• Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice.
• Public Health Aspects of Dehydrated Foods. Progress Report of the Committee on Foods (Except Milk): Food and Nutrition Section.
• Report of the Committee on Foods (Except Milk). (Public Health Aspects of Dehydrated Foods) : Food and Nutrition Section.
• Separate movement planning and spatial assimilation effects in sequential bimanual aiming movements.
• Superlinearly converging dimer method for transition state search.
• The resolution of chloroquine, SN 7618.
• The role of hyaluronidase in experimental streptococcal infection.
• Thoracic response to dynamic, non-impact loading from a hub, distributed belt, diagonal belt, and double diagonal belts.
• Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina.