Pitavastatin: Protection against Neuronal Retinal Damage Induced by Ischemia-Reperfusion Injury in Rats.

Pitavastatin: Protection against Neuronal Retinal Damage Induced by Ischemia-Reperfusion Injury in Rats. Research Abstract Details 

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Pitavastatin: Protection against Neuronal Retinal Damage Induced by Ischemia-Reperfusion Injury in Rats. Abstract Text:

Takahiro Kawaji,Yasuya Inomata,Akiomi Takano,Nina Sagara,Masaru Inatani,Mikiko Fukushima,Hidenobu Tanihara,Megumi Honjo,Takahiro Kawaji,Yasuya Inomata,Akiomi Takano,Nina Sagara,Masaru Inatani,Mikiko Fukushima,Hidenobu Tanihara,Megumi Honjo,Takahiro Kawaji,Yasuya Inomata,Akiomi Takano,Nina Sagara,Masaru Inatani,Mikiko Fukushima,Hidenobu Tanihara,Megumi Honjo,

Purpose: To evaluate the neuroprotective effects of pitavastatin against neuronal retinal damage induced by ischemia-reperfusion injury in rats. Methods and Results: Ischemia-reperfusion injury was induced in Sprague-Dawley rats using ocular hypertension. Pitavastatin (0.1, 0.5, or 1.0 mg/kg) was given intravenously 12 hr or 5 min before, or 12 or 24 hr after the induction of ischemia-reperfusion injury. Morphometric and retrograde labeling analyses revealed neuroprotective effects when pitavastatin (0.5 mg/kg) was administered 5 min before - even 12 and 24 hr - after induction of ischemia-reperfusion injury. These effects depended on dose; protection was noted at pitavastatin concentrations of 0.5 and 1 mg/kg but not 0.1 mg/kg. Furthermore, preadministration of pitavastatin (0.5 mg/kg) reduced expression of P-selectin and intercellular adhesion molecule-1 at 12 and 24 hr after induction of ischemia-reperfusion injury. Conclusions: As pitavastatin was efficacious in preventing retinal neuronal death, it may be a novel therapeutic modality for ischemic retinal diseases.

Pitavastatin: Protection against Neuronal Retinal Damage Induced by Ischemia-Reperfusion Injury in Rats. Publishing Authors By Initials

T Kawaji,Y Inomata,A Takano,N Sagara,M Inatani,M Fukushima,H Tanihara,M Honjo,T Kawaji,Y Inomata,A Takano,N Sagara,M Inatani,M Fukushima,H Tanihara,M Honjo,T Kawaji,Y Inomata,A Takano,N Sagara,M Inatani,M Fukushima,H Tanihara,M Honjo,

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Pitavastatin: Protection against Neuronal Retinal Damage Induced by Ischemia-Reperfusion Injury in Rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current eye research

VOLUME: 32

Page Numbers: 991-7

Journal Abbreviation: Curr. Eye Res.

ISSN: 0271-3683

DAY: 20

MONTH: Nov

YEAR: 2007

Pitavastatin: Protection against Neuronal Retinal Damage Induced by Ischemia-Reperfusion Injury in Rats. Information

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LANGUAGE: eng

NlmUniqueID: 8104312

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Grant and Affiliation Information for Pitavastatin: Protection against Neuronal Retinal Damage Induced by Ischemia-Reperfusion Injury in Rats.

AFFILIATION: Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan.

Country: England

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MEDLINETA: Curr Eye Res

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