[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats]

[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats] Abstract Text:

Jun Li,Yumin Lv,Xiuyun Dong,Zhu Jin,

OBJECTIVE: To investigate the chemopreventive effects of pioglitazone (exogenous PPAR gamma ligand) on rat colon aberrant crypt foci, a rat carcinogenesis model induced by dimethylhydrazine (DMH), and to compare pioglitazone with sulindac (a NSAID). METHODS: Thirty-two, 8-week-old, female Sprague-Dawley rats were randomly divided into four groups (n = 8 each). Group 1 rats were injected with DMH alone (120 mg.kg-1, single subcutaneous injection). Group 2 rats were injected with saline alone. Group 3 rats were pre-treated with sulindac (320 mg.kg-1) for 7 days before DMH initiation. Group 4 rats were treated with pioglitazone (100 mg.kg-1). The animals were killed at the end of the experiment (week 5) and the colons were stained with methylene blue. The aberrant crypt foci (ACF) of the colonic mucosa were assessed. RESULTS: In Group 1 rats (DMH only), the average numbers of ACF/colon and AC/colon were (182 +/- 93) and (263 +/- 198), respectively. In Group 2 (saline group) rats, no ACF were found. In Group 3 (sulindac group) rats, the average numbers of ACF/colon and AC/colon were (91 +/- 49) and (140 +/- 69), respectively. Both of them were decreased significantly compared with the values in Group 1 (P < 0.01 and P < 0.05). In Group 4 (pioglitazone group) rats, the average numbers of ACF/colon and AC/colon were (97 +/- 23) and (148 +/- 31), respectively. Both of them were decreased significantly compared with the values in Group 1 (P < 0.01 and P < 0.05). No difference was found in the values of Group 3 and Group 4. CONCLUSION: These results suggest that pioglitazone have chemopreventive effects against rat colon carcinogenesis induced by DMH, whose effect is similar to that of sulindac.

[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats] Publishing Authors By Initials

J Li,Y Lv,X Dong,Z Jin,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe

VOLUME: 35

Page Numbers: 537-9

Journal Abbreviation: Beijing Da Xue Xue Bao

ISSN: 1671-167X

DAY: 6

MONTH: Oct

YEAR: 2003

[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 101125284

[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats]

AFFILIATION: Department of Digestive Disease, Peking University Third Hospital, Beijing 100083, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Beijing Da Xue Xue Bao

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine DMH induced aberrant crypt foci in rats Related Publications

• AP-1 complexes mediate oxidized LDL-induced overproduction of TGF-beta(1) in rat mesangial cells.
• Daily short-term head-up tilt can prevent structural changes in arteries of tail-suspended rats.
• Urethral reconstruction with colonic mucosa in treatment of complex urethral stricture.
• [Animal models of schizophrenia using different laboratory mouse strains]
• [Apoptosis-inducing ligand TRAIL can be recruited to lipid rafts]
• [Application of BACTEC MGIT 960 system and molecular identification of mycobacteria in the diagnosis of spinal tuberculosis]
• [CD226 monoclonal antibody induces variation of intracytosolic free calcium level in human umbilical vein endothelial cells]
• [Cloning, prokaryotic expression of LAIR and identification of their immunological reactivities]
• [Development and preliminary application of a double mAb sandwich ELISA for detecting soluble CD226]
• [Development of conductance measurement technique for permeability of monolayer endothelial cells]
• [Diagnosis and treatment of methylmalonic acidemia in 14 cases]
• [Effect of low-intensity microwave of on mitomycin C-induced genotoxicity in vitro]
• [Effects of TGF beta on BMP-2 gene transfection cells in vitro]
• [Effects of human BMP2 gene transfection on NIH3T3 cells in vitro]
• [Effects of perindopril on plasma soluble TRAIL and receptor soluble DR5 in patients with congestive heart failure]
• [Establishment of a sandwich ELISA for detecting serum sTRAIL and its application]
• [Eukaryotic expression and application of human CD226 Ig fusion protein containing 3C protease-restricted site]
• [General development situation of space food for space station]
• [High polymorphism at the human P gene locus in Chinese Han and Tibetan populations]
• [Mitogenesis of platelet-derived growth factors to human osteoblasts modulated by basic fibroblast growth factor]
• [Morphological evidence on participating in adhesive function of human umbilical vein endothelial cells by CD226]
• [One case of congenital intranasal cephalocele]
• [Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats]
• [Preparation and characterization of monoclonal antibodies against human transmembrane activator and calcium modulator and cyclophilin ligand interactor]
• [Preparation, characterization and application of monoclonal antibodies to Fc fragment of Ig fusion protein]
• [Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method]
• [The acute effects of dimethoate on the muscarinic-receptors of rat brains and the relationship between muscarinic-receptors and cholinesterase]
• [The combination of cyclosporin A and androgen in the treatment of chronic aplastic anemia]
• [The evaluation of LFH or LFPH in the treatment of advanced cancer of gastric cardia and colorectal cancer]
• [Treatment of childhood leukemia with unrelated donor allogeneic bone marrow transplantation]