Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala.

Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala. Research Abstract Details 

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Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala. Abstract Text:

Rohan A Davis,Moana M Simpson,Ryan B Nugent,Anthony R Carroll,Vicky M Avery,Topul Rali,Huawei Chen,Barbara Qurallo,Ronald J Quinn,

Bioassay-guided fractionation of an organic extract from the leaves of Cupaniopsis macropetala resulted in the isolation of a new alkaloid, galloyl tyramine ( 1), together with the known flavonoid glycoside quercitrin ( 2). The structure of 1 was determined following 1D and 2D NMR, IR, UV, and MS data analysis. Compounds 1 and 2 displayed IC 50 values of 161 and 25 microM, respectively, in a Pim2 enzyme assay.

Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala. Publishing Authors By Initials

RA Davis,MM Simpson,RB Nugent,AR Carroll,VM Avery,T Rali,H Chen,B Qurallo,RJ Quinn,

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Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of natural products

VOLUME: 71

Page Numbers: 451-2

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 29

MONTH: 12

YEAR: 2007

Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala. Information

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LANGUAGE: eng

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AFFILIATION: r.quinn@griffith.edu.au.

Country: United States

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MEDLINETA: J Nat Prod

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