Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms.

Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. Research Abstract Details 

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Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. Abstract Text:

Vasu Sheeba,Vijay K Sharma,Huaiyu Gu,Yu-Ting Chou,Diane K O'Dowd,Todd C Holmes,Vasu Sheeba,Vijay K Sharma,Huaiyu Gu,Yu-Ting Chou,Diane K O'Dowd,Todd C Holmes,

Circadian pacemaker circuits consist of ensembles of neurons, each expressing molecular oscillations, but how circuit-wide coordination of multiple oscillators regulates rhythmic physiological and behavioral outputs remains an open question. To investigate the relationship between the pattern of oscillator phase throughout the circadian pacemaker circuit and locomotor activity rhythms in Drosophila, we perturbed the electrical activity and pigment dispersing factor (PDF) levels of the lateral ventral neurons (LNv) and assayed their combinatorial effect on molecular oscillations in different parts of the circuit and on locomotor activity behavior. Altered electrical activity of PDF-expressing LNv causes initial behavioral arrhythmicity followed by gradual long-term emergence of two concurrent short- and long-period circadian behavioral activity bouts in approximately 60% of flies. Initial desynchrony of circuit-wide molecular oscillations is followed by the emergence of a novel pattern of period (PER) synchrony whereby two subgroups of dorsal neurons (DN1 and DN2) exhibit PER oscillation peaks coinciding with two activity bouts, whereas other neuronal subgroups exhibit a single PER peak coinciding with one of the two activity bouts. The emergence of this novel pattern of circuit-wide oscillator synchrony is not accompanied by concurrent change in the electrical activity of the LNv. In PDF-null flies, altered electrical activity of LNv drives a short-period circadian activity bout only, indicating that PDF-independent factors underlie the short-period circadian activity component and that the long-period circadian component is PDF-dependent. Thus, polyrhythmic behavioral patterns in electrically manipulated flies are regulated by circuit-wide coordination of molecular oscillations and electrical activity of LNv via PDF-dependent and -independent factors.

Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. Publishing Authors By Initials

V Sheeba,VK Sharma,H Gu,YT Chou,DK O'Dowd,TC Holmes,V Sheeba,VK Sharma,H Gu,YT Chou,DK O'Dowd,TC Holmes,

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Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuroscience : the official journal

VOLUME: 28

Page Numbers: 217-27

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 2

MONTH: Jan

YEAR: 2008

Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

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Grant and Affiliation Information for Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms.

AFFILIATION: Department of Physiology and Biophysics, University of California, Irvine, California 92612, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS27501

ACRONYM: NS

MEDLINETA: J Neurosci

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