Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production.

Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Abstract Text:

Jiunn-Kae Chang,Ya-Ling Hsu,I-Chun Teng,Po-Lin Kuo,

Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene) is a polyphenol present in grapes and wine. By means of alkaline phosphatase activity and osteocalcin enzyme-linked immunosorbent assay (ELISA), we have shown that piceatannol exhibits a significant induction of differentiation in immortalized fetal osteoblasts (hFOB), and osteosarcoma cells (MG-63). Alkaline phosphatase and osteocalcin are phenotypic markers for early-stage differentiated osteoblasts and terminally differentiated osteoblasts, respectively, our results indicate that piceatannol stimulate osteoblast differentiation at various stages (from maturation to terminally differentiated osteoblasts). Induction of differentiation by piceatannol was associated with increased bone morphogenetic protein-2 (BMP-2) production. Addition of purified BMP-2 protein did not increase the upregulation of alkaline phosphatase activity and osteocalcin secretion by piceatannol, whereas the BMP-2 antagonist noggin blocked piceatannol and BMP-2-mediated alkaline phosphatase activity, and osteocalcin secretion enhancement, indicating that BMP-2 production is required in piceatannol-mediated osteoblast maturation and differentiation. In conclusion, piceatannol increased BMP-2 synthesis, and this effect may contribute to its action on the induction of osteoblasts maturation and differentiation, followed by an increase of bone mass. Decreases in new bone formation, followed by estrogen deficiency or various pathologic factors, may contribute to the mechanisms involved in postmenopausal osteoporosis.

Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Publishing Authors By Initials

JK Chang,YL Hsu,IC Teng,PL Kuo,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

MEDLINE DATE:

Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pharmacology

VOLUME: 551

Page Numbers: 1-9

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 8

MONTH: 09

YEAR: 2006

Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1254354

Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: drug effects

Chemical & Substance for Abstract: Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Information

Substance Name: Alkaline Phosphatase

Registry Number: EC 3.1.3.1

Grant and Affiliation Information for Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production.

AFFILIATION: Cell Biology Laboratory, Department of Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Pharmacol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production Related Publications

• (-)-Fargesol, A New Lignan from the Flowers Buds of Magnolia fargesii.
• A FIELD SURVEY OF ARTHROPOD PARASITES OF BIRDS IN TAIWAN.
• A Novel Morphinandienone Alkaloid from Fissistigma oldhamii.
• A Possible Link Between Exercise-training Adaptation And Dehydroepiandrosterone Sulfate- An Oldest-old Female Study: 1590: Board #80 May 30 3:30 PM - 5:00 PM.
• Alpha-tocopherol acetate significantly suppressed the increase in heart interstitial 8-hydroxydeoxyguanosine following myocardial ischemia and reperfusion in anesthetized rats.
• Characterization of the PC4 binding domain and its interactions with HNF4alpha.
• Cotinine characterization and quality effect of sperm for smoking and nonsmoking students.
• Do content and format affect older consumers' use of comparative information in a Medicare health plan choice? Results from a controlled experiment.
• Effect Of Ambient Oxygen Status On Liver And Muscle Glycogen Storages During Post-exercise Recovery Period: 1761: Board #49 May 31 9:00 AM 10:30 AM.
• Effect Of Dehydroepiandrosterone Administration On Recovery Capacity During Training Session In Male Badminton Players: 2581: Board #128 June 2 9:30 AM - 11:00 AM.
• Effect of detrusor function on the therapeutic outcome of a suburethral sling procedure using a polypropylene sling for stress urinary incontinence in women.
• Exercise training restores coronary arteriolar dilation to NOS activation distal to coronary artery occlusion: role of hydrogen peroxide.
• Extracellular proton-modulated pore-blocking effect of the anticonvulsant felbamate on NMDA channels.
• Extramedullary hemopoiesis with littoral cell angioma involving main and accessory spleens.
• Field theory in two-time physics with N=1 supersymmetry.
• Glucose Tolerance And Insulin Sensitivity Following A 1-week Volleyball Competition: 1754: Board #42 May 31 9:00 AM 10:30 AM.
• Molecular cloning and gene expression of the gonadotropin-releasing hormone receptor in the orange-spotted grouper, Epinephelus coioides.
• Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.
• Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production.
• Prader-Willi syndrome in Taiwan.
• QT interval is prolonged but QT dispersion is maintained in patients with primary aldosteronism.
• Simulation of water quality and plankton dynamics in the Danshuei River estuary, Taiwan.
• Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.
• Tanshinlactone A from Salvia miltiorrhiza modulates interleukin-2 and interferon-gamma gene expression.
• The Magnitude of Physiological Response to Altitude is Associated with Individual Variation in DHEA-S Levels: 925: June 1 4:30 PM - 4:45 PM.
• The advantages of a rolling foot in human walking.
• Using finger tip blood as a diabetes prevention tool: 1536: board #26 may 30 2:00 PM - 3:30 PM.
• Vascular endothelial growth factor: biology and therapeutic applications.
• Vehicle and enhancer effects on human skin penetration of aminophylline from cream formulations: evaluation in vivo.
• Visual and haptic feedback contribute to tuning and online control during object manipulation.