[Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats]

[Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats] Abstract Text:

Yi-He Wang,Sheng Wang,Rui-Rong He,

The purpose of this study was to determine the effect of phytoestrogen genistein (GST) on carotid sinus baroreflex in 30 anesthetized male rats by perfusing the isolated carotid sinus in vivo. The results obtained are as follows. (1) By perfusion with GST (50 micromol/L), the functional curve of baroreflex was shifted to the right and upward, with a peak slope (PS) decrease from 0.36+/-0.01 to 0.23+/-0.01 (P<0.001) and a reflex decrease (RD) in mean arterial pressure from 39.75+/-1.58 to 27.00+/-0.60 mmHg (P<0.001), while the threshold pressure (TP) and saturation pressure (SP) were significantly increased from 65.63+/-2.1 to 82.05+/-1.95 mmHg (P<0.001) and from 192.23+/-3.90 to 215.76+/-3.75 mmHg (P<0.001), respectively. Among the functional parameters of carotid baroreflex, the changes in RD, PS and TP were dose-dependent. (2) Pretreatment with Bay K 8644 (500 nmol/L), an agonist of calcium channels, could completely abolish the inhibitory effect of GST on carotid baroreflex. (3) Preperfusion with an inhibitor of NO synthase, L-NAME (100 micromol/L), did not affect the inhibitory effect of GST. It is proposed that the inhibitory action of GST on carotid baroreflex may be mediated by the inhibition of Ca(2+) channel of vascular smooth muscle, but not by NO release from endothelium.

[Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats] Publishing Authors By Initials

YH Wang,S Wang,RR He,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 54

Page Numbers: 354-8

Journal Abbreviation:

ISSN: 0371-0874

DAY: 25

MONTH: Aug

YEAR: 2002

[Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 20730130

[Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats]

AFFILIATION: Department of Physiology, Medical College of Chinese People's Armed Police Forces, Tianjin 300162.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Sheng Li Xue Bao

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats Related Publications

• Action of genistein on tension of isolated rabbit femoral artery and its mechanism.
• Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.
• Effect of agmatine on intracellular free calcium concentration in isolated rat ventricular myocytes.
• Effects of pregnancy cocaine exposure on the mother and fetus: a murine model.
• Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells.
• Isolation, culture and identification of human venous malformation endothelial cells.
• Microinjection of adrenomedullin into rostral ventrolateral medulla increases blood pressure, heart rate and renal sympathetic nerve activity in rats.
• Responses of regional vascular beds to local injection of genistein in rats.
• [A case of nt 1004C --> A G6PD gene mutation in Yunnan Han people]
• [A serial study of in cytogenetic change and morphology on the tetra-arsenic tetra-sulfide treatment in untreated or recurrent acute promyelocytic leukemia]
• [An experimental study on the prevention and treatment of postburn intestinal injury and bacterial translocation by Sijunzi decoction in scalded rats]
• [Diagnosis and treatment of primary hyperparathyroidism]
• [Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells]
• [Effect of curcumin on STAT5 signaling molecule in K562 cells]
• [Eosinophil specific active markers in allergy]
• [Expressions of peripheral lymph node addressin and GlcNAc-6-sulfotransferase in endometrium and their impacts on implantation.]
• [Generation of human monoclonal antibodies against hemorrhagic fever with renal sydrome (HFRS) virus]
• [Investigation of nuclear Ca2+ regulation in the isolated cardiac nuclei]
• [Mechanism of the role of electrical field in electrical injury]
• [Modulatory effects of capsaicin-sensitive nerve fiber on cardiovascular activity]
• [Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats]
• [Preparation and characterization of a McAb against tissue factor pathway inhibitor]
• [Pulmonary alveolar proteinosis: a report of 2 cases, with literature review]
• [Stimulation single fiber electromyography in rats with myasthenia induced by organophosphorus insecticides and their mixtures poisoning]
• [Study of correlation dimension on EEG]
• [The effect of V-shaped Niti alloy implantation on acetabular dysplasia: an experimental study]
• [The polymorphism of delta-aminolevulinic acid dehydratase and genetic susceptibility to lead toxicity in Uighur and Yi population in China]
• [The relationship between nm23-H1 loss of heterozygosity and metastasis in hepatocellular carcinoma]
• [Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios]
• [Treatment of nodular vasculitis based on syndrome differentiation: a report of 32 cases]