Physiological roles of the -substituted alanine synthase gene family in Arabidopsis.

Physiological roles of the -substituted alanine synthase gene family in Arabidopsis. Research Abstract Details 

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Physiological roles of the -substituted alanine synthase gene family in Arabidopsis. Abstract Text:

Mutsumi Watanabe,Miyako Kusano,Akira Oikawa,Atsushi Fukushima,Masaaki Noji,Kazuki Saito,Mutsumi Watanabe,Miyako Kusano,Akira Oikawa,Atsushi Fukushima,Masaaki Noji,Kazuki Saito,Mutsumi Watanabe,Miyako Kusano,Akira Oikawa,Atsushi Fukushima,Masaaki Noji,Kazuki Saito,

The beta-substituted alanine (Ala) synthase (Bsas) family in the large superfamily of pyridoxal 5'-phosphate-dependent enzymes comprises cysteine (Cys) synthase (CSase) [O-acetyl-serine (thiol) lyase] and beta-cyano-Ala synthase (CASase) in plants. Nine genomic sequences encode putative Bsas proteins in Arabidopsis thaliana. The physiological roles of these Bsas isoforms in vivo were investigated by the characterization of T-DNA insertion mutants. Analyses of gene expression, activities of CSase and CASase, and levels of Cys and glutathione in the bsas mutants indicated that cytosolic Bsas1;1, plastidic Bsas2;1, and mitochondrial Bsas2;2 play major roles in Cys biosynthesis. Cytosolic Bsas1;1 has the most dominant contribution both in leaf and root, and mitochondrial Bsas2;2 plays a significant role in root. Mitochondrial Bsas3;1 is a genuine CASase. Nontargeted metabolome analyses of knockout mutants were carried out by a combination of gas chromatography time-of-flight mass spectrometry and capillary electrophoresis time-of-flight mass spectrometry. The level of gamma-glutamyl-beta-cyano-Ala decreased in the mutant bsas3;1, indicating the crucial role of Bsas3;1 in beta-cyano-Ala metabolism in vivo.

Physiological roles of the -substituted alanine synthase gene family in Arabidopsis. Publishing Authors By Initials

M Watanabe,M Kusano,A Oikawa,A Fukushima,M Noji,K Saito,M Watanabe,M Kusano,A Oikawa,A Fukushima,M Noji,K Saito,M Watanabe,M Kusano,A Oikawa,A Fukushima,M Noji,K Saito,

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Physiological roles of the -substituted alanine synthase gene family in Arabidopsis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Plant physiology

VOLUME: 146

Page Numbers: 310-20

Journal Abbreviation: Plant Physiol.

ISSN: 0032-0889

DAY: 16

MONTH: 11

YEAR: 2007

Physiological roles of the -substituted alanine synthase gene family in Arabidopsis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Physiological roles of the -substituted alanine synthase gene family in Arabidopsis.

AFFILIATION: Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

Country: United States

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MEDLINETA: Plant Physiol

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