Physiological role of L-type ca(2+) channels in marginal cells in the stria vascularis of Guinea pigs.

Physiological role of L-type ca(2+) channels in marginal cells in the stria vascularis of Guinea pigs. Research Abstract Details 

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Physiological role of L-type ca(2+) channels in marginal cells in the stria vascularis of Guinea pigs. Abstract Text:

Takaki Inui,Yoshiaki Mori,Masahito Watanabe,Atsuko Takamaki,Junko Yamaji,Yoshiro Sohma,Ryotaro Yoshida,Hiroshi Takenaka,Takahiro Kubota,

Using immunohistochemical and electrophysiological methods, we investigated the role of L-type Ca(2+) channels in the regulation of the endocochlear potential (EP) of the endolymphatic surface cells (ESC) of the guinea pig stria vascularis. The following findings were made: (1) Administration of 30 microg/ml nifedipine via a vertebral artery significantly suppressed the transient asphyxia-induced decrease in the EP (TAID) and the transient asphyxia-induced increase in the Ca(2+), referred to as TAIICa, concentration in the endolymph ([Ca](e)). (2) The endolymphatic administration of 1 microg/ml nifedipine significantly inhibited the TAID as well as the TAIICa. The endolymphatic administration of nifedipine (0.001-10 microg/ml) inhibited the TAID in a dose-dependent manner. (3) The endolymphatic administration of (+)-Bay K8644, an L-type Ca(2+) channel closer, significantly inhibited the TAID, whereas (-)-Bay K8644, an L-type Ca(2+) channel opener, caused a large decrease in the EP from approximately +75 mV to approximately +20 mV at 10 min after the endolymphatic administration. (4) By means of immunohistochemistry, a positive staining reaction with L-type Ca(2+) channels was detected in the marginal cells of the stria vascularis. (5) Under the high [Ca](e) condition, we examined the mechanism of the TAIICa and hypothesized that the TAIICa might have been caused by the decrease in the EP through a shunt pathway in the ESC. (6) The administration of nifedipine to the endolymph significantly inhibited the Ba(2+)-induced decrease in the EP. These findings support the view that L-type Ca(2+) channels in the marginal cells regulate the EP, but not directly the TAIICa.

Physiological role of L-type ca(2+) channels in marginal cells in the stria vascularis of Guinea pigs. Publishing Authors By Initials

T Inui,Y Mori,M Watanabe,A Takamaki,J Yamaji,Y Sohma,R Yoshida,H Takenaka,T Kubota,

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Physiological role of L-type ca(2+) channels in marginal cells in the stria vascularis of Guinea pigs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The journal of physiological sciences : JPS

VOLUME: 57

Page Numbers: 287-98

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ISSN: 1880-6546

DAY: 29

MONTH: 10

YEAR: 2007

Physiological role of L-type ca(2+) channels in marginal cells in the stria vascularis of Guinea pigs. Information

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LANGUAGE: eng

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AFFILIATION: Department of Otolaryngology, Osaka Medical College, Takatsuki, Osaka, 569-8686 Japan. ph2008@art.osaka-med.ac.jp.

Country: Japan

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MEDLINETA: J Physiol Sci

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