Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans.

Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Research Abstract Details 

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Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Abstract Text:

Yan Guo,Lijun Ma,Pablo J Enriori,Juraj Koska,Paul W Franks,Thomas Brookshire,Michael A Cowley,Arline D Salbe,Angelo Delparigi,P Antonio Tataranni,

OBJECTIVE: To explore the potential role of the endogenous peptide YY (PYY) in the long-term regulation of body weight and energy homeostasis. RESEARCH METHODS AND PROCEDURES: Fasting and postprandial plasma PYY concentrations were measured after an overnight fast and 30 to 180 minutes after a standardized meal in 29 (21 men/8 women) non-diabetic subjects, 16 of whom had a follow-up visit 10.8 +/- 1.4 months later. Ratings of hunger and satiety were collected using visual analog scales. Resting metabolic rate (RMR) (15-hour RMR) and respiratory quotient (RQ) were assessed using a respiratory chamber. RESULTS: Fasting PYY concentrations were negatively correlated with various markers of adiposity and negatively associated with 15-hour RMR (r = -0.46, p = 0.01). Postprandial changes in PYY (area under the curve) were positively associated with postprandial changes in ratings of satiety (r = 0.47, p = 0.01). The maximal PYY concentrations achieved after the meal (peak PYY) were negatively associated with 24-hour RQ (r = -0.41, p = 0.03). Prospectively, the peak PYY concentrations were negatively associated with changes in body weight (r = -0.58, p = 0.01). DISCUSSION: Our data indicate that the endogenous PYY may be involved in the long-term regulation of body weight. It seems that this long-term effect was not exclusively driven by the modulation of food intake but also by the control of energy expenditure and lipid metabolism.

Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Publishing Authors By Initials

Y Guo,L Ma,PJ Enriori,J Koska,PW Franks,T Brookshire,MA Cowley,AD Salbe,A Delparigi,PA Tataranni,

For similar satiation: satiety response research abstracts see: satiation: satiety response research

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Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Obesity (Silver Spring, Md.)

VOLUME: 14

Page Numbers: 1562-70

Journal Abbreviation: Obesity (Silver Spring)

ISSN: 1930-7381

DAY: 21

MONTH: Sep

YEAR: 2006

Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Information

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LANGUAGE: eng

NlmUniqueID: 101264860

Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Keywords Mesh Terms:

KEYWORDS: Satiety Response

MESH TERMS: physiology

Chemical & Substance for Abstract: Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans.

AFFILIATION: Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. yanguo@phx.niddk.nih.gov

Country: United States

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MEDLINETA: Obesity (Silver Spring)

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